依美昔单抗
化合物
依美昔单抗（INN：ecromeximab；开发代号：KW2871）是一种嵌合单克隆抗体，正在开发用于治疗恶性黑色素瘤。[1][2]该药物被用来针对转移性黑色素瘤进行I期临床试验，[3]并在随后与高剂量的干扰素α2b联合进行了II期临床试验。[4][5]
| 单克隆抗体 | |
|---|---|
| 种类 | 完整抗体 |
| 目標 | GD3神经节苷脂 |
| 臨床資料 | |
| ATC碼 |
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| 识别信息 | |
| CAS号 | 292819-64-8  |
| ChemSpider |
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| UNII | |
| 化学信息 | |
| 摩尔质量 | 145255 g/mol |
该药物由协和发酵工业株式会社开发。截至2015年12月，开发已停止。[6]
参考资料
- ^ Statement On A Nonproprietary Name Adopted By The USAN Council - Ecromeximab （页面存档备份，存于互联网档案馆）, American Medical Association.
- ^ Clinical trial number NCT00679289 for "Phase II Study of KW2871 Combined With High Dose Interferon-alpha2b in Patients With Metastatic Cutaneous Melanoma" at ClinicalTrials.gov
- ^ Forero, Andres; Shah, Jatin; Carlisle, Ronda; Triozzi, Pierre L.; LoBuglio, Albert F.; Wang, Wen-Quan; Fujimori, Matt; Conry, Robert M. A phase I study of an anti-GD3 monoclonal antibody, KW-2871, in patients with metastatic melanoma. Cancer Biotherapy & Radiopharmaceuticals. 2006-12, 21 (6) [2024-03-06]. ISSN 1084-9785. PMID 17257071. doi:10.1089/cbr.2006.21.561. （原始内容存档于2024-06-04）.
- ^ Phase II Study of KW2871 Combined With High Dose Interferon-α2b in Patients With Metastatic Melanoma - Full Text View - ClinicalTrials.gov. clinicaltrials.gov. [2024-03-06]. （原始内容存档于2021-04-10） （英语）.
- ^ Tarhini, Ahmad A.; Moschos, Stergios J.; Lin, Yan; Lin, Hui-Min; Sander, Cindy; Yin, Yan; Venhaus, Ralph; Gajewski, Thomas F.; Kirkwood, John M. Safety and efficacy of the antiganglioside GD3 antibody ecromeximab (KW2871) combined with high-dose interferon-α2b in patients with metastatic melanoma. Melanoma Research. 2017-08, 27 (4) [2024-03-06]. ISSN 1473-5636. PMID 28489678. doi:10.1097/CMR.0000000000000353. （原始内容存档于2024-06-03）.
- ^ Adis insight: Ecromeximab. [2024-03-06]. （原始内容存档于2017-01-03）.