右旋甲状腺素

右旋甲状腺素,英文:Dextrothyroxine,商品名:Choloxin,是甲状腺素右旋异构体[1]起初该化合物被研发,以用于降胆固醇药物[2],但由于其心脏副作用而被退出市场。该药物会增加肝脂肪酶,从而提高甘油三酯的利用率并降低血清中脂蛋白(a)的水平。[3]

右旋甲状腺素
臨床資料
商品名英语Drug nomenclatureCholoxin
其他名稱D-3,5,3',5'-tetraiodothyronine
AHFS/Drugs.comMultum消费者信息
ATC碼
法律規範狀態
法律規範
  • Discontinued
识别信息
  • (2R)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic acid
CAS号51-49-0
PubChem CID
DrugBank
ChemSpider
UNII
ChEBI
ChEMBL
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
ECHA InfoCard100.000.094 編輯維基數據鏈接
化学信息
化学式C15H11I4NO4
摩尔质量776.87 g·mol−1
3D模型(JSmol英语JSmol
  • O=C(O)[C@H](N)Cc2cc(I)c(Oc1cc(I)c(O)c(I)c1)c(I)c2
  • InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m1/s1
  • Key:XUIIKFGFIJCVMT-GFCCVEGCSA-N

参见

参考文献

  1. ^ Dextrothyroxine (Code C61719). NCI Thesaurus. National Cancer Institute. 2011-11-14 [2020-01-28]. (原始内容存档于2023-05-22). 
  2. ^ Bantle JP, Hunninghake DB, Frantz ID, Kuba K, Mariash CN, Oppenheimer JH. Comparison of effectiveness of thyrotropin-suppressive doses of D- and L-thyroxine in treatment of hypercholesterolemia. The American Journal of Medicine. September 1984, 77 (3): 475–81. PMID 6475988. doi:10.1016/0002-9343(84)90107-4. 
  3. ^ Bommer C, Werle E, Walter-Sack I, Keller C, Gehlen F, Wanner C, et al. D-thyroxine reduces lipoprotein(a) serum concentration in dialysis patients. Journal of the American Society of Nephrology. January 1998, 9 (1): 90–6. PMID 9440092.