咪洛克生
化合物
咪洛克生（INN：imiloxan）是一种用于科学研究的药物。它作为α2B肾上腺素受体的选择性拮抗剂，[1]可用于区分不同α2肾上腺素亚型的作用。[2][3]
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| CAS号 | 81167-16-0  |
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| 化学式 | C14H16N2O2 |
| 摩尔质量 | 244.29 g·mol−1 |
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合成
参考资料
- ^ Michel AD, Loury DN, Whiting RL. Assessment of imiloxan as a selective alpha 2B-adrenoceptor antagonist. British Journal of Pharmacology. March 1990, 99 (3): 560–4. PMC 1917331
. PMID 1970500. doi:10.1111/j.1476-5381.1990.tb12968.x.
- ^ Cobos-Puc LE, Villalón CM, Sánchez-López A, Lozano-Cuenca J, Pertz HH, Görnemann T, Centurión D. Pharmacological evidence that alpha2A- and alpha2C-adrenoceptors mediate the inhibition of cardioaccelerator sympathetic outflow in pithed rats. European Journal of Pharmacology. January 2007, 554 (2–3): 205–11. PMID 17109851. doi:10.1016/j.ejphar.2006.09.068.
- ^ Romero TR, de Castro Perez A, de Francischi JN, Gama Duarte ID. Probable involvement of alpha(2C)-adrenoceptor subtype and endogenous opioid peptides in the peripheral antinociceptive effect induced by xylazine. European Journal of Pharmacology. April 2009, 608 (1–3): 23–7. PMID 19236861. doi:10.1016/j.ejphar.2009.02.019 .
- ^ Caroon JM, Clark RD, Kluge AF, Olah R, Repke DB, Unger SH, et al. Structure-activity relationships for 2-substituted imidazoles as alpha 2-adrenoceptor antagonists. Journal of Medicinal Chemistry. June 1982, 25 (6): 666–70. PMID 6124635. doi:10.1021/jm00348a012.
