地屈孕酮
化合物
地屈孕酮(英語:Dydrogesterone,缩写DYD,商品名为Duphaston等)是一种黄体制剂药物,用于治疗一系列疾病,包括妊娠期的习惯性流产,黃體期缺陷(LPD)造成的功能失调性子宫出血和不孕,經痛,子宮內膜異位症,继发性閉經,月经周期紊乱,经前综合症,是激素替代療法的选用药物之一[4],通常由口服给药[4]。
臨床資料 | |
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商品名 | Duphaston, others |
其他名稱 | Isopregnenone; Dehydroprogesterone; Didrogesteron; 6-Dehydroretroprogesterone; 9β,10α-Pregna-4,6-diene-3,20-dione; NSC-92336[1][2] |
AHFS/Drugs.com | 国际药品名称 |
给药途径 | By mouth |
藥物類別 | Progestin; Progestogen |
ATC碼 | |
法律規範狀態 | |
法律規範 |
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藥物動力學數據 | |
生物利用度 | 28%[3] |
血漿蛋白結合率 | ? (probably to albumin)[3][4] |
药物代谢 | Hepatic: AKR1C1, AKR1C3, CYP3A4[7][5] |
代謝產物 | 20α-DHD (exclusively via AKR1C1 and AKRC13)[5] |
生物半衰期 | Parent: 5–7 hours[6] Metabolite: 14–17 hours[6] |
排泄途徑 | Urine |
识别信息 | |
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CAS号 | 152-62-5 |
PubChem CID | |
DrugBank | |
ChemSpider | |
UNII | |
KEGG | |
ChEBI | |
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.005.280 |
化学信息 | |
化学式 | C21H28O2 |
摩尔质量 | 312.446 g/mol |
3D模型(JSmol) | |
熔点 | 144 °C(291 °F) |
沸点 | 463 °C(865 °F) |
水溶性 | Insoluble mg/mL (20 °C) |
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参考文献
- ^ J. Elks. The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. 14 November 2014: 474– [2019-06-09]. ISBN 978-1-4757-2085-3. (原始内容存档于2020-08-03).
- ^ Index Nominum 2000: International Drug Directory. Taylor & Francis. January 2000: 378–. ISBN 978-3-88763-075-1.
- ^ 3.0 3.1 ((Howard JA Carp, MB, BS, FRCOG)). Progestogens in Obstetrics and Gynecology. Springer. 9 April 2015: 33, 38. ISBN 978-3-319-14385-9. 温哥华格式错误 (帮助)
- ^ 4.0 4.1 4.2 Kuhl H. Pharmacology of estrogens and progestogens: influence of different routes of administration. Climacteric. 2005,. 8 Suppl 1: 3–63. PMID 16112947. doi:10.1080/13697130500148875.
- ^ 5.0 5.1 Beranič, N.; Gobec, S.; Rižner, T. Lanišnik. Progestins as inhibitors of the human 20-ketosteroid reductases, AKR1C1 and AKR1C3. Chemico-Biological Interactions. 2011, 191 (1–3): 227–233. ISSN 0009-2797. PMID 21182831. doi:10.1016/j.cbi.2010.12.012.
- ^ 6.0 6.1 Bińkowska, Małgorzata; Woroń, Jarosław. Progestogens in menopausal hormone therapy. Menopausal Review. 2015, 14 (2): 134–143. ISSN 1643-8876. PMC 4498031 . PMID 26327902. doi:10.5114/pm.2015.52154.
- ^ Olbrich, Matthias; Weigl, Kevin; Kahler, Elke; Mihara, Katsuhiro. Dydrogesterone metabolism in human liver by aldo-keto reductases and cytochrome P450 enzymes. Xenobiotica. 2016, 46 (10): 868–874. ISSN 0049-8254. PMID 26796435. doi:10.3109/00498254.2015.1134852.