森沙夫定
化合物
(重定向自森沙戊定)
森沙夫定(英語:Censavudine,开发代码:BMS-986001,也称为4'-乙炔基司他夫定,4'-ethynylstavudine)是一种含氮有机化合物,化学式为C12H12N2O4,由百时美施贵宝作为HIV抑制剂开发。[1][2]
臨床資料 | |
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其他名稱 | 4'-ethynylstavudine, festinavir |
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识别信息 | |
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CAS号 | 634907-30-5 |
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NIAID ChemDB | |
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.225.812 |
化学信息 | |
化学式 | C12H12N2O4 |
摩尔质量 | 248.24 g·mol−1 |
3D模型(JSmol) | |
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参考文献
- ^ Wu VH, Smith RA, Masoum S, Raugi DN, Ba S, Seydi M, et al. MK-8591 (4'-Ethynyl-2-Fluoro-2'-Deoxyadenosine) Exhibits Potent Activity against HIV-2 Isolates and Drug-Resistant HIV-2 Mutants in Culture. Antimicrobial Agents and Chemotherapy. August 2017, 61 (8). PMC 5527656 . PMID 28559249. doi:10.1128/AAC.00744-17.
- ^ Gupta SK, McComsey GA, Lombaard J, Echevarría J, Orrell C, Avihingsanon A, et al. Efficacy, safety, bone and metabolic effects of HIV nucleoside reverse transcriptase inhibitor BMS-986001 (AI467003): a phase 2b randomised, controlled, partly blinded trial. The Lancet. HIV. January 2016, 3 (1): e13–22. PMID 26762988. doi:10.1016/S2352-3018(15)00231-3. hdl:1805/10552 .