硫酸雌酮

硫酸雌酮(英語:Estrone sulfate,缩写E1S或称为雌酮-3-硫酸,estrone 3-sulfate)是一种天然内源性甾体物质,属于雌激素酯雌激素缀合物英语estrogen conjugate[1][2][3]。除了天然荷尔蒙之外,硫酸雌酮还可以作为激素替代療法中的药物

硫酸雌酮
Skeletal formula of estrone sulfate
Space-filling model of the estrone sulfate molecule
IUPAC名
[(8R,9S,13S,14S)-13-methyl-17-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-yl] hydrogen sulfate
别名 E1S; Oestrone sulfate; Estrone 3-sulfate; Estra-1,3,5(10)-trien-17-one 3-sulfate
识别
CAS号 481-97-0
438-67-5 (sodium salt)
PubChem 3001028
ChemSpider 2272513
SMILES
 
  • C[C@]12CC[C@H]3[C@H]([C@@H]1CCC2=O)CCC4=C3C=CC(=C4)OS(=O)(=O)O
InChI
 
  • 1S/C18H22O5S/c1-18-9-8-14-13-5-3-12(23-24(20,21)22)10-11(13)2-4-15(14)16(18)6-7-17(18)19/h3,5,10,14-16H,2,4,6-9H2,1H3,(H,20,21,22)/t14-,15-,16+,18+/m1/s1
InChIKey JKKFKPJIXZFSSB-CBZIJGRNSA-N
ChEBI 17474
DrugBank DB04574
KEGG C02538
性质
化学式 C18H22O5S
摩尔质量 350.43 g·mol−1
若非注明,所有数据均出自标准状态(25 ℃,100 kPa)下。

参考文献

  1. ^ Rezvanpour A, Don-Wauchope AC. Clinical implications of estrone sulfate measurement in laboratory medicine. Crit Rev Clin Lab Sci. March 2017, 54 (2): 73–86. PMID 27960570. doi:10.1080/10408363.2016.1252310. 
  2. ^ Lobo RA. Treatment of the Postmenopausal Woman: Basic and Clinical Aspects. Academic Press. 5 June 2007: 768– [2019-06-10]. ISBN 978-0-08-055309-2. (原始内容存档于2016-12-21). 
  3. ^ Kuhl H. Pharmacology of estrogens and progestogens: influence of different routes of administration (PDF). Climacteric. 2005,. 8 Suppl 1: 3–63 [2019-06-10]. PMID 16112947. doi:10.1080/13697130500148875. (原始内容存档 (PDF)于2019-03-27).