科罗索酸

化合物

科罗索酸(英語:Corosolic acid)化学式C30H48O4,是一种五环三萜化合物,最初提取自大花紫薇Lagerstroemia speciosa)。科罗索酸与熊果酸C30H48O3)结构上非常类似,仅多了一个2α位的羟基[2]

科罗索酸
Chemical structure of corosolic acid
IUPAC名
(1S,2R,4aS,6aR,6aS,6bR,8aR,10R,11R,12aR,14bS)-10,11-Dihydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxylic acid
别名 Glucosol; Corsolic acid; Colosic acid; 2α-Hydroxyursolic acid
识别
CAS号 4547-24-4  checkY
PubChem 6918774
ChemSpider 5293965
SMILES
 
  • O=C(O)[C@@]54[C@H](/C3=C/C[C@H]1[C@](CC[C@@H]2[C@]1(C)C[C@@H](O)[C@H](O)C2(C)C)(C)[C@]3(C)CC4)[C@@H](C)[C@H](C)CC5
InChI
 
  • 1/C30H48O4/c1-17-10-13-30(25(33)34)15-14-28(6)19(23(30)18(17)2)8-9-22-27(5)16-20(31)24(32)26(3,4)21(27)11-12-29(22,28)7/h8,17-18,20-24,31-32H,9-16H2,1-7H3,(H,33,34)/t17-,18+,20-,21+,22-,23+,24+,27+,28-,29-,30+/m1/s1
InChIKey HFGSQOYIOKBQOW-ZSDYHTTIBC
性质
化学式 C30H48O4
摩尔质量 472.7 g·mol−1
熔点 274—276 °C(547—549 K)[1]
若非注明,所有数据均出自标准状态(25 ℃,100 kPa)下。
熊果酸的结构

参考文献

  1. ^ Phuong Thien Thuong, Byung-Sun Min, WenYi Jin, MinKyun Na, JongPill Lee, RackSeon Seong, Young-Mi Lee, KyungSik Song, YeonHee Seong, Hyeong-Kyu Lee, KiHwan Bae, Sam Sik Kang. Anti-complementary Activity of Ursane-Type Triterpenoids from Weigela subsessilis. Biological & Pharmaceutical Bulletin. 2006, 29 (4): 830–833 [2019-12-14]. ISSN 0918-6158. doi:10.1248/bpb.29.830 (英语). 
  2. ^ Kosuke Baba, Reiko Hiramatsu, Benjamart Suradej, Riho Tanigaki, Sayaka Koeda, Tomonori Waku, Takao Kataoka. Asiatic Acid, Corosolic Acid, and Maslinic Acid Interfere with Intracellular Trafficking and N-Linked Glycosylation of Intercellular Adhesion Molecule-1. Biological and Pharmaceutical Bulletin. 2018-12-01, 41 (12): 1757–1768 [2019-12-14]. ISSN 0918-6158. doi:10.1248/bpb.b18-00276. (原始内容存档于2022-06-17) (英语).