罗雄龙

罗雄龙
臨床資料
其他名稱	SH-434、17α-丙基美睾酮、17β-羟基-1α-甲基-17α-丙基-5α-雄-3-酮
给药途径	局部给药
识别信息
	IUPAC命名法 (1S,5S,8R,9S,10S,13S,14S,17S)-17-hydroxy-1,10,13-trimethyl-17-propyl-2,4,5,6,7,8,9,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-3-one; ;
CAS号	79243-67-7
PubChem CID	71232;
ChemSpider	64367;
UNII	3L5C5C8ZNG;
ChEMBL	ChEMBL2107498;
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)	DTXSID801033022 ;
ECHA InfoCard	100.071.904
化学信息
化学式	C23H38O2
摩尔质量	346.56 g·mol−1
3D模型（JSmol（英语：JSmol））	交互式图像;
	SMILES CCCC1(CCC2C1(CCC3C2CCC4C3(C(CC(=O)C4)C)C)C)O;
	InChI InChI=1S/C23H38O2/c1-5-10-23(25)12-9-19-18-7-6-16-14-17(24)13-15(2)22(16,4)20(18)8-11-21(19,23)3/h15-16,18-20,25H,5-14H2,1-4H3/t15-,16-,18-,19-,20-,21-,22-,23-/m0/s1; Key:IMFNBOMNWHWKQD-MXENSADDSA-N;

罗雄龙（INN：rosterolone；开发代号：SH-434），也叫17α-丙基美睾酮（17α-propylmesterolone）是一种类固醇抗雄激素，于1984年首次被描述，开发用于局部给药，但从未上市。^[1]^[2]它在治疗痤疮方面显示出一定的功效，但无论是局部还是全身给药都缺乏全身作用。^[3]^[1]^[2]

参考资料

^ ^1.0 ^1.1 Luderschmidt C, Eiermann W, Jawny J, Bidlingmaier F, Ring J. 17 alpha-Propylmesterolone (SH 434): an antiandrogenic sebosuppressive substance not influencing circulating testosterone concentrations. Experimental studies in Syrian hamsters. Naunyn-Schmiedeberg's Archives of Pharmacology. December 1984, 328 (2): 214–8. PMID 6527707. S2CID 26451613. doi:10.1007/BF00512076.
^ ^2.0 ^2.1 Singh SM, Gauthier S, Labrie F. Androgen receptor antagonists (antiandrogens): structure-activity relationships. Current Medicinal Chemistry. February 2000, 7 (2): 211–47. PMID 10637363. doi:10.2174/0929867003375371.
^ Neumann F, Töpert M. Antiandrogens and Hair Growth: Basic Concepts and Experimental Research. Orfanos CE, Happle R (编). Hair and Hair Diseases. Springer. 1990: 791–826. ISBN 978-3-642-74614-7. doi:10.1007/978-3-642-74612-3_34.

这是一篇关于类固醇的小作品。您可以通过编辑或修订扩充其内容。

这是一篇与皮肤药相关小作品。您可以通过编辑或修订扩充其内容。

[LuderschmidtEiermann1984-1] 1.0 ^1.1 Luderschmidt C, Eiermann W, Jawny J, Bidlingmaier F, Ring J. 17 alpha-Propylmesterolone (SH 434): an antiandrogenic sebosuppressive substance not influencing circulating testosterone concentrations. Experimental studies in Syrian hamsters. Naunyn-Schmiedeberg's Archives of Pharmacology. December 1984, 328 (2): 214–8. PMID 6527707. S2CID 26451613. doi:10.1007/BF00512076.

[SinghGauthier2000-2] 2.0 ^2.1 Singh SM, Gauthier S, Labrie F. Androgen receptor antagonists (antiandrogens): structure-activity relationships. Current Medicinal Chemistry. February 2000, 7 (2): 211–47. PMID 10637363. doi:10.2174/0929867003375371.

[NeumannTöpert1990-3] Neumann F, Töpert M. Antiandrogens and Hair Growth: Basic Concepts and Experimental Research. Orfanos CE, Happle R (编). Hair and Hair Diseases. Springer. 1990: 791–826. ISBN 978-3-642-74614-7. doi:10.1007/978-3-642-74612-3_34.

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