苯并噻二嗪

化合物

苯并噻二嗪是一种双环杂环衍生物,杂环含有两个和一个[1]

苯并噻二嗪
IUPAC名
2H-1,2,4-Benzothiadiazine
识别
CAS号 255-18-5  checkY
PubChem 473368
ChemSpider 10660057
SMILES
 
  • c1ccc2SN\N=C/c2c1
InChI
 
  • 1/C7H6N2S/c1-2-4-7-6(3-1)5-8-9-10-7/h1-5,9H
InChIKey HAVZTGSQJIEKPI-UHFFFAOYAH
性质
化学式 C7H6N2S
摩尔质量 150.2 g·mol−1
若非注明,所有数据均出自标准状态(25 ℃,100 kPa)下。

一些苯并噻二嗪衍生物可用作药物,包括:

氢氯噻嗪,一种苯并噻二嗪衍生物,用作利尿剂

参考资料

  1. ^ Hu Z, Martí J, Lu H. Structure of benzothiadiazine at zwitterionic phospholipid cell membranes. The Journal of Chemical Physics. October 2021, 155 (15): 154303. Bibcode:2021JChPh.155o4303H. PMID 34686044. S2CID 239471390. arXiv:2107.14565 . doi:10.1063/5.0065163. 
  2. ^ 2.0 2.1 Hu Z, Marti J. In Silico Drug Design of Benzothiadiazine Derivatives Interacting with Phospholipid Cell Membranes. Membranes. March 2022, 12 (3): 331. PMC 8949146 . PMID 35323806. doi:10.3390/membranes12030331 . 
  3. ^ Huwaimel BI, Bhakta M, Kulkarni CA, Milliken AS, Wang F, Peng A, et al. Discovery of Halogenated Benzothiadiazine Derivatives with Anticancer Activity*. ChemMedChem. April 2021, 16 (7): 1143–1162. PMC 8035258 . PMID 33331124. doi:10.1002/cmdc.202000729. 
  4. ^ Varano F, Catarzi D, Colotta V, Squarcialupi L, Matucci R. 1,2,4-Benzothiadiazine-1,1-dioxide derivatives as ionotropic glutamate receptor ligands: synthesis and structure-activity relationships. Archiv der Pharmazie. November 2014, 347 (11): 777–785. PMID 25204434. S2CID 1765795. doi:10.1002/ardp.201400192. 
  5. ^ Ganeshpurkar A, Gutti G, Singh SK. Chapter 1 - RNA-Dependent RNA Polymerases and Their Emerging Roles in Antiviral Therapy. SP (编). Viral Polymerases. Academic Press. 2019-01-01: 1–42. ISBN 978-0-12-815422-9. S2CID 92095885. doi:10.1016/B978-0-12-815422-9.00001-2 (英语).