雷米克仑

化合物

雷米克仑(英語:Remikiren)是一款用于抗高血压肾素抑制剂。它由罗氏制药首先于1996年推出。[1]

雷米克仑
臨床資料
ATC碼
藥物動力學數據
血漿蛋白結合率83%
识别信息
  • (2S)-2-[(2R)-2-benzyl-3-(2-methylpropane-2-sulfonyl)propanamido]-N-[(2R,3S,4R)-1-cyclohexyl-4-cyclopropyl-3,4-dihydroxybutan-2-yl]-3-(1H-imidazol-4-yl)propanamide
CAS号126222-34-2  checkY
PubChem CID
DrugBank
ChemSpider
KEGG
ChEMBL
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
化学信息
化学式C33H50N4O6S
摩尔质量630.839 g/mol
3D模型(JSmol英语JSmol
  • O=S(=O)(C(C)(C)C)C[C@H](C(=O)N[C@H](C(=O)N[C@@H](CC1CCCCC1)[C@@H](O)[C@@H](O)C2CC2)Cc3cncn3)Cc4ccccc4
  • InChI=1S/C33H50N4O6S/c1-33(2,3)44(42,43)20-25(16-22-10-6-4-7-11-22)31(40)37-28(18-26-19-34-21-35-26)32(41)36-27(17-23-12-8-5-9-13-23)30(39)29(38)24-14-15-24/h4,6-7,10-11,19,21,23-25,27-30,38-39H,5,8-9,12-18,20H2,1-3H3,(H,34,35)(H,36,41)(H,37,40)/t25-,27+,28+,29+,30-/m1/s1 checkY
  • Key:UXIGZRQVLGFTOU-VQXQMPIVSA-N checkY

参考资料

  1. ^ Richter WF, Whitby BR, Chou RC. Distribution of remikiren, a potent orally active inhibitor of human renin, in laboratory animals. Xenobiotica. 1996, 26 (3): 243–54. PMID 8730917. doi:10.3109/00498259609046705.