11-脱氢皮质酮

化合物

11-脱氢皮质酮(英語:11-Dehydrocorticosterone,缩写11-DHC,或称为17-脱氧可的松17-deoxycortisone21-羟基孕-4-烯-3,11,20-三酮,21-hydroxypregn-4-ene-3,11,20-trione)是一种有机化合物,化学式为C21H28O4,是一种内源性的盐皮质激素[1]

11-脱氢皮质酮
IUPAC名
21-Hydroxypregn-4-ene-3,11,20-trione
系统名
(1S,3aS,3bS,9aR,9bS,11aS)-1-(Hydroxyacetyl)-9a,11a-dimethyl-2,3,3a,3b,4,5,8,9,9a,9b,11,11a-dodecahydro-1H-cyclopenta[a]phenanthrene-7,10-dione
别名 11-DHC; 11-Oxocorticosterone; 17-Deoxycortisone
识别
CAS号 72-23-1
PubChem 5311364
ChemSpider 4470861
SMILES
 
  • C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2C(=O)C[C@]4([C@H]3CC[C@@H]4C(=O)CO)C
ChEBI 78600
性质
化学式 C21H28O4
摩尔质量 344.44 g·mol−1
若非注明,所有数据均出自标准状态(25 ℃,100 kPa)下。

参考文献

  1. ^ Harno, E; Cottrell, EC; Keevil, BG; DeSchoolmeester, J; Bohlooly-Y, M; Andersén, H; Turnbull, AV; Leighton, B; White, A. 11-Dehydrocorticosterone causes metabolic syndrome, which is prevented when 11β-HSD1 is knocked out in livers of male mice.. Endocrinology. 2013-10, 154 (10): 3599–609. PMID 23832962. doi:10.1210/en.2013-1362. 

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