3,4-二羟基苯基乙二醇

化合物

3,4-二羟基苯基乙二醇是一种有机化合物,化学式为C8H10O4,它可以邻苯二酚氯乙酰氯为原料反应制得。[3]它和溴化苄碳酸钾存在下于丙酮中回流反应,可以得到3,4-二苄氧基苯基乙二醇。[4]

3,4-二羟基苯基乙二醇
IUPAC名
4-(1,2-Dihydroxyethyl)benzene-1,2-diol
识别
CAS号 3343-19-9  checkY
PubChem 91528
ChemSpider 82648
SMILES
 
  • C1=CC(=C(C=C1C(CO)O)O)O
InChI
 
  • 1/C8H10O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8-12H,4H2
InChIKey MTVWFVDWRVYDOR-UHFFFAOYAY
ChEBI 1387
KEGG C05576
MeSH Dihydroxyphenylethylene+glycol
性质
化学式 C8H10O4
摩尔质量 170.16 g·mol−1
密度 1.481±0.06 g·cm−3[1]
熔点 128—129 °C(401—402 K)[2]
溶解性 21.4 g(25 °C)[1]
若非注明,所有数据均出自标准状态(25 ℃,100 kPa)下。

参考文献

  1. ^ 1.0 1.1 Calculated using Advanced Chemistry Development (ACD/Labs) Software V11.02 (© 1994-2022 ACD/Labs). Retrieved from SciFinder. [2022-3-15].
  2. ^ J. D. Benigni, Anthony J. Verbiscar. The Synthesis of Two New Metabolites of Catecholamines: 3,4-Dihydroxyphenylethyleneglycol and 4-Hydroxy-3-methoxyphenylethyleneglycol 1. Journal of Medicinal Chemistry. 1963-09, 6 (5): 607–608 [2022-03-15]. ISSN 0022-2623. doi:10.1021/jm00341a035. (原始内容存档于2022-03-15) (英语). 
  3. ^ Kalampaliki, Giannouli, Skaltsounis, Kostakis. A Three-Step, Gram-Scale Synthesis of Hydroxytyrosol, Hydroxytyrosol Acetate, and 3,4-Dihydroxyphenylglycol. Molecules. 2019-09-05, 24 (18): 3239 [2022-03-15]. ISSN 1420-3049. doi:10.3390/molecules24183239. (原始内容存档于2022-03-15) (英语). 
  4. ^ Fernandez-Bolanos Guzman, Jose Maria; Maya Castilla, Ines; Gonzalez Benjumea, Alejandro; Lopez Garcia, Ma Angeles; Alarcon de la Lastra Romero, Catalina; Villegas Lama, Ma Isabel; Sanchez Fidalgo, Susana; Aparicio Soto, Marina. Novel anti-inflammatory agents based on polyphenols of the olive tree. 2015 WO 2015044470 A1.