A2058 (亦稱ATCC CRL-11147)是人類惡性黑色素瘤細胞系,最初分離自一位43歲的人類男性轉移性腦癌英语Brain metastasis患者[1]。A2058細胞具有高度移動特性,並且表達神經生長因子英语Nerve growth factor[2]神經生長因子受體[3]。高度醣基化的CD93跨膜蛋白分佈在A2058細胞的細胞膜,尤其在細胞與細胞接觸的位置,其延展面積載體控制細胞為大,並且促進細胞間緊密的接觸,故而加入CD93抗體及耗盡細胞培養基中的離子會破壞以CD93蛋白作為媒介的A2058細胞貼附[4]。有研究指出蜜蜂蜂毒會誘發A2058細胞的凋亡,短時間內便可令胞體外與內質網的鈣離子進入細胞內,所以鈣離子在細胞內的濃度會快速上升[5]

參考資料

  1. ^ Todaro, GJ; Fryling, C; De Larco, JE. Transforming growth factors produced by certain human tumor cells: polypeptides that interact with epidermal growth factor receptors.. Proceedings of the National Academy of Sciences of the United States of America. 1980-09, 77 (9): 5258–62 [2019-12-06]. PMID 6254071. doi:10.1073/pnas.77.9.5258. 
  2. ^ Fabricant, RN; De Larco, JE; Todaro, GJ. Nerve growth factor receptors on human melanoma cells in culture.. Proceedings of the National Academy of Sciences of the United States of America. 1977-02, 74 (2): 565–9 [2019-12-06]. PMID 265522. doi:10.1073/pnas.74.2.565. 
  3. ^ Sherwin, SA; Sliski, AH; Todaro, GJ. Human melanoma cells have both nerve growth factor and nerve growth factor-specific receptors on their cell surfaces.. Proceedings of the National Academy of Sciences of the United States of America. 1979-03, 76 (3): 1288–92 [2019-12-06]. PMID 375235. doi:10.1073/pnas.76.3.1288. 
  4. ^ CHEN Hu-yan, WANG Shang-shang, JIANG Min, ZHANG Qiao-an, CHEN Lian-jun. Inhibitory effect of microRNA-205 on migration and invasion of melanoma cell lines and its related mechanism. Academic Journal of Second Military Medical University, 2017, 38(5): 576-82 [2019-12-06]
  5. ^ Tu, WC; Wu, CC; Hsieh, HL; Chen, CY; Hsu, SL. Honeybee venom induces calcium-dependent but caspase-independent apoptotic cell death in human melanoma A2058 cells.. Toxicon : official journal of the International Society on Toxinology. 2008-08-01, 52 (2): 318–29 [2019-12-06]. PMID 18602939. doi:10.1016/j.toxicon.2008.06.007. 

外部連結