DCLK1

位於13號人類染色體的基因

双肾上腺皮质激素样激酶1(英語:Doublecortin like kinase 1,缩写DCLK1)是一种丝氨酸/苏氨酸激酶,在人类基因组中由DCLK1 基因编码[6][7][8],在肠道上皮的丛细胞(Tuft cell)中大量表达,也是胃肠道肿瘤干细胞分子标志物[9]

DCLK1
已知的結構
PDB直系同源搜索: PDBe RCSB
識別號
别名DCLK1;, CL1, CLICK1, DCAMKL1, DCDC3A, DCLK, doublecortin like kinase 1
外部IDOMIM604742 MGI1330861 HomoloGene130530 GeneCardsDCLK1
相關疾病
肥胖症[1]
基因位置(人类
13號染色體
染色体13號染色體[2]
13號染色體
DCLK1的基因位置
DCLK1的基因位置
基因座13q13.3起始35,768,652 bp[2]
终止36,131,382 bp[2]
RNA表达模式


查阅更多表达数据
直系同源
物種人類小鼠
Entrez
Ensembl
UniProt
mRNA​序列
蛋白序列
基因位置​(UCSC)Chr 13: 35.77 – 36.13 MbChr 3: 55.15 – 55.45 Mb
PubMed​查找[4][5]
維基數據
檢視/編輯人類檢視/編輯小鼠

参考文献

  1. ^ 與DCLK1相關的疾病;在維基數據上查看/編輯參考. 
  2. ^ 2.0 2.1 2.2 GRCh38: Ensembl release 89: ENSG00000133083 - Ensembl, May 2017
  3. ^ 3.0 3.1 3.2 GRCm38: Ensembl release 89: ENSMUSG00000027797 - Ensembl, May 2017
  4. ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  5. ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  6. ^ Omori Y, Suzuki M, Ozaki K, Harada Y, Nakamura Y, Takahashi E, Fujiwara T. Expression and chromosomal localization of KIAA0369, a putative kinase structurally related to Doublecortin. J Hum Genet. Oct 1998, 43 (3): 169–77. PMID 9747029. doi:10.1007/s100380050063 . 
  7. ^ Sossey-Alaoui K, Srivastava AK. DCAMKL1, a brain-specific transmembrane protein on 13q12.3 that is similar to doublecortin (DCX). Genomics. May 1999, 56 (1): 121–6. PMID 10036192. doi:10.1006/geno.1998.5718. 
  8. ^ Entrez Gene: DCAMKL1 doublecortin and CaM kinase-like 1. 
  9. ^ DCLK1的空间结构和理化性质分析. 生物信息学. 2018-12-11, 16 (4): 231–238. doi:10.12113/j.issn.1672-5565.201712002. 

延伸阅读

  • Nagase T, Ishikawa K, Nakajima D, et al. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.. DNA Res. 1997, 4 (2): 141–50. PMID 9205841. doi:10.1093/dnares/4.2.141 . 
  • Matsumoto N, Pilz DT, Ledbetter DH. Genomic structure, chromosomal mapping, and expression pattern of human DCAMKL1 (KIAA0369), a homologue of DCX (XLIS).. Genomics. 1999, 56 (2): 179–83. PMID 10051403. doi:10.1006/geno.1998.5673. 
  • Lin PT, Gleeson JG, Corbo JC, et al. DCAMKL1 encodes a protein kinase with homology to doublecortin that regulates microtubule polymerization.. J. Neurosci. 2001, 20 (24): 9152–61. PMID 11124993. doi:10.1523/JNEUROSCI.20-24-09152.2000 . 
  • Burgess HA, Reiner O. Alternative splice variants of doublecortin-like kinase are differentially expressed and have different kinase activities.. J. Biol. Chem. 2002, 277 (20): 17696–705. PMID 11884394. doi:10.1074/jbc.M111981200 . 
  • Kim MH, Derewenda U, Devedjiev Y, et al. Purification and crystallization of the N-terminal domain from the human doublecortin-like kinase.. Acta Crystallogr. D. 2003, 59 (Pt 3): 502–5. PMID 12595708. doi:10.1107/S0907444903000027. 
  • Kim MH, Cierpicki T, Derewenda U, et al. The DCX-domain tandems of doublecortin and doublecortin-like kinase.. Nat. Struct. Biol. 2003, 10 (5): 324–33. PMID 12692530. doi:10.1038/nsb918. 
  • Seet LF, Liu N, Hanson BJ, Hong W. Endofin recruits TOM1 to endosomes.. J. Biol. Chem. 2004, 279 (6): 4670–9. PMID 14613930. doi:10.1074/jbc.M311228200 . 
  • Ballif BA, Villén J, Beausoleil SA, et al. Phosphoproteomic analysis of the developing mouse brain.. Mol. Cell. Proteomics. 2005, 3 (11): 1093–101. PMID 15345747. doi:10.1074/mcp.M400085-MCP200 . 

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