ERG11甾醇-14-去甲基酶(Sterol 14-demethylase)是一种真菌细胞色素P450,最初发现于酿酒酵母Saccharomyces cerevisiae基因组,属于CYP51家族,代号CYP51F1[1]。ERG11催化羊毛甾醇转化为酵母甾醇的第一步,羊毛甾醇的14α-去甲基化生成4,4-二甲基-5α-胆甾-8(9),14,24-三烯-3β-醇,酵母甾醇会进一步生成麦角固醇[2]

Sterol 14-demethylase
标识
生物 Saccharomyces cerevisiae
符号 ERG11
可选符号 CYP51F1
Entrez 856398
RefSeq (mRNA) NM_001179137
RefSeq (蛋白质) NP_011871
UniProt P10614
其他数据
EC number 1.14.14.154
染色体 VIII: 0.12 - 0.12 Mb

参考文献

  1. ^ Ghaemmaghami S, Huh WK, Bower K, Howson RW, Belle A, Dephoure N, et al. Global analysis of protein expression in yeast. Nature. October 2003, 425 (6959): 737–41. Bibcode:2003Natur.425..737G. PMID 14562106. doi:10.1038/nature02046. 
  2. ^ Mo C, Bard M. Erg28p is a key protein in the yeast sterol biosynthetic enzyme complex. Journal of Lipid Research. September 2005, 46 (9): 1991–8. PMID 15995173. doi:10.1194/jlr.M500153-JLR200.