GRIA1(英語:glutamate receptor, ionotropic, AMPA 1)是由GRIA1 基因編碼的蛋白质[7][8]

GRIA1
識別號
别名GRIA1;, GLUH1, GLUR1, GLURA, GluA1, HBGR1, glutamate ionotropic receptor AMPA type subunit 1, Glutamate receptor, ionotropic, AMPA 1
外部IDOMIM138248 MGI95808 HomoloGene20226 GeneCardsGRIA1
相關疾病
肥胖症[1]
為以下藥物的標靶
(S)-AMPA、​茴拉西坦、​cx516、​CX546、​环噻嗪、​IDRA-21、​吡拉西坦、​S-18986、​LY-300168、​GYKI-2466、​NBQX、​tezampanel、​argiotoxin、​Joro toxin、​dasolampanel、​Irampanel、​selurampanel、​zonampanel、​托吡酯[2]
基因位置(人类
5號染色體
染色体5號染色體[3]
5號染色體
GRIA1的基因位置
GRIA1的基因位置
基因座5q33.2起始153,489,615 bp[3]
终止153,813,869 bp[3]
直系同源
物種人類小鼠
Entrez
Ensembl
UniProt
mRNA​序列

NM_001113325
​NM_001252403
​NM_008165

蛋白序列

NP_001106796
​NP_001239332
​NP_032191

基因位置​(UCSC)Chr 5: 153.49 – 153.81 MbChr 11: 56.9 – 57.22 Mb
PubMed​查找[5][6]
維基數據
檢視/編輯人類檢視/編輯小鼠

交互作用

GRIA1與以下蛋白質有交互作用:

參見

參考

  1. ^ 與GRIA1相關的疾病;在維基數據上查看/編輯參考. 
  2. ^ 對GRIA1起作用的藥物;在維基數據上查看/編輯參考. 
  3. ^ 3.0 3.1 3.2 GRCh38: Ensembl release 89: ENSG00000155511 - Ensembl, May 2017
  4. ^ 4.0 4.1 4.2 GRCm38: Ensembl release 89: ENSMUSG00000020524 - Ensembl, May 2017
  5. ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  6. ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  7. ^ Puckett C, Gomez CM, Korenberg JR, Tung H, Meier TJ, Chen XN, Hood L. Molecular cloning and chromosomal localization of one of the human glutamate receptor genes. Proc Natl Acad Sci U S A. October 1991, 88 (17): 7557–61. PMC 52340 . PMID 1652753. doi:10.1073/pnas.88.17.7557. 
  8. ^ McNamara JO, Eubanks JH, McPherson JD, Wasmuth JJ, Evans GA, Heinemann SF. Chromosomal localization of human glutamate receptor genes. J Neurosci. July 1992, 12 (7): 2555–62. PMID 1319477. 
  9. ^ Gardoni F, Mauceri D, Fiorentini C, Bellone C, Missale C, Cattabeni F, Di Luca M. CaMKII-dependent phosphorylation regulates SAP97/NR2A interaction. J. Biol. Chem. November 2003, 278 (45): 44745–52. PMID 12933808. doi:10.1074/jbc.M303576200. 
  10. ^ Leonard AS, Davare MA, Horne MC, Garner CC, Hell JW. SAP97 is associated with the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor GluR1 subunit. J. Biol. Chem. July 1998, 273 (31): 19518–24. PMID 9677374. doi:10.1074/jbc.273.31.19518. 
  11. ^ Sans N, Racca C, Petralia RS, Wang YX, McCallum J, Wenthold RJ. Synapse-associated protein 97 selectively associates with a subset of AMPA receptors early in their biosynthetic pathway. J. Neurosci. October 2001, 21 (19): 7506–16. PMID 11567040. 
  12. ^ Shen L, Liang F, Walensky LD, Huganir RL. Regulation of AMPA receptor GluR1 subunit surface expression by a 4. 1N-linked actin cytoskeletal association. J. Neurosci. November 2000, 20 (21): 7932–40. PMID 11050113. 
  13. ^ Kohda K, Kamiya Y, Matsuda S, Kato K, Umemori H, Yuzaki M. Heteromer formation of delta2 glutamate receptors with AMPA or kainate receptors. Brain Res. Mol. Brain Res. January 2003, 110 (1): 27–37. PMID 12573530. doi:10.1016/s0169-328x(02)00561-2. 

深入閱讀

外部連結


GRIA1引用了美国国家医学图书馆提供的資料,这些資料属于公共领域