N-苯乙基哌啶

化合物

N-苯乙基哌啶(英語:1-(2-phenylethyl)piperidine,或称为1-苯乙基哌啶,开发代号:AC927),分子式C13H19N,是一种选择性的σ-受体受体拮抗剂[1]

N-苯乙基哌啶
识别信息
  • 1-(2-phenylethyl)piperidine or N-phenethyl-piperidine
CAS号332-14-9  checkY
ChemSpider
UNII
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
ECHA InfoCard100.005.785 編輯維基數據鏈接
化学信息
化学式C13H19N
摩尔质量189.30 g·mol−1

合成

N-苯乙基哌啶可由哌啶苯乙烯在一种有机镁化合物的催化下反应制得。[2]

参考文献

  1. ^ Matsumoto RR, Shaikh J, Wilson LL, Vedam S, Coop A. Attenuation of methamphetamine-induced effects through the antagonism of sigma (σ) receptors: Evidence from in vivo and in vitro studies. Eur. Neuropsychopharmacol. 2008, 18 (12): 871–81. PMC 2688716 . PMID 18755577. doi:10.1016/j.euroneuro.2008.07.006. 
  2. ^ Davin, Laia; Hernán-Gómez, Alberto; McLaughlin, Calum; Kennedy, Alan R.; McLellan, Ross; Hevia, Eva. Alkali metal and stoichiometric effects in intermolecular hydroamination catalysed by lithium, sodium and potassium magnesiates. Dalton Transactions (Royal Society of Chemistry (RSC)). 2019, 48 (23): 8122–8130. ISSN 1477-9226. doi:10.1039/c9dt00923j.