SIN3A
位於15號人類染色體的基因
成对两亲性螺旋蛋白SIN3A（英語：Paired amphipathic helix protein Sin3a）是一个由人类基因SIN3A编码的蛋白质[1][2]。
功能
SIN3A是一种转录调控蛋白，包含有成对两亲性螺旋结构域（paired amphipathic helix，PAH），对蛋白质互作非常重要[3]。
互作
SIN3A与下列蛋白有相互作用：
- CABIN1[4]
- HBP1,[5]
- HDAC1,[6][7][8][9][10][11][12][13][14][15][16][17][18][19]
- HDAC9,[20][21]
- Histone deacetylase 2,[6][8][9][14][15][22][23]
- Host cell factor C1,[24][25]
- IKZF1,[20][26][27]
- ING1,[19]
- KLF11,[28][29]
- MNT,[30]
- MXD1,[5][31][32]
- Methyl-CpG-binding domain protein 2,[33]
- Nuclear receptor co-repressor 2,[18][34]
- OGT[35]
- PHF12,[36]
- 早幼粒细胞白血病蛋白[37]
- RBBP4,[38][39]
- RBBP7,[19][39]
- SAP130,[8]
- SAP30,[8][13][19][36][39][40]
- SMARCA2,[41]
- SMARCA4,[19][41]
- SMARCC1,[19][41]
- SUDS3,[8][42]
- TAL1,[43] and
- Zinc finger and BTB domain-containing protein 16.[44][45][46]
另见
参考文献
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- ^ Entrez Gene: SIN3A SIN3 homolog A, transcription regulator (yeast).
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- ^ 41.0 41.1 41.2 Sif S, Saurin AJ, Imbalzano AN, Kingston RE. Purification and characterization of mSin3A-containing Brg1 and hBrm chromatin remodeling complexes. Genes Dev. 2001, 15 (5): 603–18. PMC 312641 . PMID 11238380. doi:10.1101/gad.872801.
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- ^ Huang S, Brandt SJ. mSin3A regulates murine erythroleukemia cell differentiation through association with the TAL1 (or SCL) transcription factor. Mol. Cell. Biol. 2000, 20 (6): 2248–59. PMC 110841 . PMID 10688671. doi:10.1128/MCB.20.6.2248-2259.2000.
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- ^ Wong CW, Privalsky ML. Components of the SMRT corepressor complex exhibit distinctive interactions with the POZ domain oncoproteins PLZF, PLZF-RARalpha, and BCL-6. J. Biol. Chem. 1998, 273 (42): 27695–702. PMID 9765306. doi:10.1074/jbc.273.42.27695.
延伸阅读
- Zhang Y, Dufau ML. Dual mechanisms of regulation of transcription of luteinizing hormone receptor gene by nuclear orphan receptors and histone deacetylase complexes.. J. Steroid Biochem. Mol. Biol. 2003, 85 (2-5): 401–14. PMID 12943729. doi:10.1016/S0960-0760(03)00230-9.
- Ayer DE, Lawrence QA, Eisenman RN. Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3.. Cell. 1995, 80 (5): 767–76. PMID 7889570. doi:10.1016/0092-8674(95)90355-0.
- Hurlin PJ, Quéva C, Koskinen PJ; et al. Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation.. EMBO J. 1996, 14 (22): 5646–59. PMC 394680 . PMID 8521822.
- Hassig CA, Fleischer TC, Billin AN; et al. Histone deacetylase activity is required for full transcriptional repression by mSin3A.. Cell. 1997, 89 (3): 341–7. PMID 9150133. doi:10.1016/S0092-8674(00)80214-7.
- Laherty CD, Yang WM, Sun JM; et al. Histone deacetylases associated with the mSin3 corepressor mediate mad transcriptional repression.. Cell. 1997, 89 (3): 349–56. PMID 9150134. doi:10.1016/S0092-8674(00)80215-9.
- Zhang Y, Iratni R, Erdjument-Bromage H; et al. Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex.. Cell. 1997, 89 (3): 357–64. PMID 9150135. doi:10.1016/S0092-8674(00)80216-0.
- Meroni G, Reymond A, Alcalay M; et al. Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor.. EMBO J. 1997, 16 (10): 2892–906. PMC 1169897 . PMID 9184233. doi:10.1093/emboj/16.10.2892.
- Lin RJ, Nagy L, Inoue S; et al. Role of the histone deacetylase complex in acute promyelocytic leukaemia.. Nature. 1998, 391 (6669): 811–4. PMID 9486654. doi:10.1038/35895.
- David G, Alland L, Hong SH; et al. Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein.. Oncogene. 1998, 16 (19): 2549–56. PMID 9627120. doi:10.1038/sj.onc.1202043.
- Wong CW, Privalsky ML. Components of the SMRT corepressor complex exhibit distinctive interactions with the POZ domain oncoproteins PLZF, PLZF-RARalpha, and BCL-6.. J. Biol. Chem. 1998, 273 (42): 27695–702. PMID 9765306. doi:10.1074/jbc.273.42.27695.
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- Tong JK, Hassig CA, Schnitzler GR; et al. Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex.. Nature. 1998, 395 (6705): 917–21. PMID 9804427. doi:10.1038/27699.
- Koipally J, Renold A, Kim J, Georgopoulos K. Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes.. EMBO J. 1999, 18 (11): 3090–100. PMC 1171390 . PMID 10357820. doi:10.1093/emboj/18.11.3090.
- Boutell JM, Thomas P, Neal JW; et al. Aberrant interactions of transcriptional repressor proteins with the Huntington's disease gene product, huntingtin.. Hum. Mol. Genet. 2000, 8 (9): 1647–55. PMID 10441327. doi:10.1093/hmg/8.9.1647.
- Zhang Y, Ng HH, Erdjument-Bromage H; et al. Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation.. Genes Dev. 1999, 13 (15): 1924–35. PMC 316920 . PMID 10444591. doi:10.1101/gad.13.15.1924.
- Kao HY, Downes M, Ordentlich P, Evans RM. Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repression.. Genes Dev. 2000, 14 (1): 55–66. PMC 316336 . PMID 10640276. doi:10.1101/gad.14.1.55.
- Huang S, Brandt SJ. mSin3A regulates murine erythroleukemia cell differentiation through association with the TAL1 (or SCL) transcription factor.. Mol. Cell. Biol. 2000, 20 (6): 2248–59. PMC 110841 . PMID 10688671. doi:10.1128/MCB.20.6.2248-2259.2000.
- Koipally J, Georgopoulos K. Ikaros interactions with CtBP reveal a repression mechanism that is independent of histone deacetylase activity.. J. Biol. Chem. 2000, 275 (26): 19594–602. PMID 10766745. doi:10.1074/jbc.M000254200.