Template:PBB/6774

Signal transducer and activator of transcription 3 (acute-phase response factor) 信号转导及转录激活蛋白3（急性期反应因子）
PDB rendering based on 1bg1.
有效结构 PDB 直系同源检索：PDBe, RCSB PDB查询代码列表 1bg1
标识
代号	STAT3; APRF; HIES
扩展标识	遗传学：102582 鼠基因：103038 同源基因：7960 ChEMBL: 4026 GeneCards: STAT3 Gene
基因本体论描述 分子功能 · RNA polymerase II repressing transcription factor binding · DNA binding · sequence-specific DNA binding transcription factor activity · signal transducer activity · ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity · calcium ion binding · protein binding · transcription factor binding · protein kinase binding · CCR5 chemokine receptor binding · glucocorticoid receptor binding · sequence-specific DNA binding · transcription regulatory region DNA binding · protein dimerization activity 细胞成分 · nucleus · nucleoplasm · nucleolus · cytoplasm · cytosol · plasma membrane 生物过程 · negative regulation of transcription from RNA polymerase II promoter · temperature homeostasis · eye photoreceptor cell differentiation · regulation of transcription, DNA-dependent · regulation of transcription from RNA polymerase II promoter · protein import into nucleus · cellular component movement · acute-phase response · signal transduction · JAK-STAT cascade · nervous system development · cell proliferation · virus-host interaction · cytokine-mediated signaling pathway · stem cell maintenance · sexual reproduction · intracellular receptor signaling pathway · response to estradiol stimulus · cellular response to hormone stimulus · regulation of multicellular organism growth · response to drug · glucose homeostasis · eating behavior · response to ethanol · positive regulation of Notch signaling pathway · positive regulation of transcription, DNA-dependent · positive regulation of transcription from RNA polymerase II promoter · neurotrophin TRK receptor signaling pathway · astrocyte differentiation · radial glial cell differentiation · growth hormone receptor signaling pathway · JAK-STAT cascade involved in growth hormone signaling pathway · interleukin-6-mediated signaling pathway Sources: Amigo / QuickGO
RNA表达模式
更多表达数据
直系同源体
物种	人类	小鼠
Entrez	6774	20848
Ensembl	ENSG00000168610	ENSMUSG00000004040
UniProt	P40763	P42227
mRNA序列	NM_003150	NM_011486
蛋白序列	NP_003141	NP_035616
基因位置	Chr 17: 40.47 – 40.54 Mb	Chr 11: 100.89 – 100.94 Mb
PubMed查询	[1]	[2]