7,8,3'-三羟基黄酮

化合物

7,8,3'-三羟基黄酮(英语:7,8,3′-Trihydroxyflavone,缩写为7,8,3'-THF)是一种黄酮类化合物7,8-二羟基黄酮衍生物,可作为脑源性神经营养因子受体TrkB小分子激动剂[1][2]

7,8,3'-三羟基黄酮
临床资料
其他名称7,8,3'-THF
ATC码
  • 未分配
识别信息
  • 7,8-Dihydroxy-2-(3-hydroxyphenyl)chromen-4-one
CAS号137502-84-2
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
化学信息
化学式C15H10O5
摩尔质量270.24 g·mol−1
3D模型(JSmol英语JSmol
  • C1=CC(=CC(=C1)O)C2=CC(=O)C3=C(O2)C(=C(C=C3)O)O
  • InChI=1S/C15H10O5/c16-9-3-1-2-8(6-9)13-7-12(18)10-4-5-11(17)14(19)15(10)20-13/h1-7,16-17,19H
  • Key:ZJZSQGDOCUHCCW-UHFFFAOYSA-N

参考文献

  1. ^ Liu X, Chan CB, Jang SW, Pradoldej S, Huang J, He K, et al. A synthetic 7,8-dihydroxyflavone derivative promotes neurogenesis and exhibits potent antidepressant effect. Journal of Medicinal Chemistry. December 2010, 53 (23): 8274–86. PMC 3150605 . PMID 21073191. doi:10.1021/jm101206p. 
  2. ^ Yu Q, Chang Q, Liu X, Gong S, Ye K, Lin X. 7,8,3'-Trihydroxyflavone, a potent small molecule TrkB receptor agonist, protects spiral ganglion neurons from degeneration both in vitro and in vivo. Biochemical and Biophysical Research Communications. June 2012, 422 (3): 387–92. PMC 3388121 . PMID 22575512. doi:10.1016/j.bbrc.2012.04.154.