UH-301

UH-301
识别信息
	IUPAC命名法 (S)-5-fluoro-8-hydroxy-2-(dipropylamino)tetralin; ;
CAS号	127126-22-1
IUPHAR/BPS	61;
UNII	1T7773JH5N;
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)	DTXSID70155410 ;
化学信息
化学式	C16H24FNO
摩尔质量	265.37 g·mol−1
3D模型（JSmol（英语：JSmol））	交互式图像;
	SMILES C2Cc1c(c(O)ccc1F)CC2N(CCC)CCC;

[S-]-UH-301，是一种科学研究中常用的研究化学品及药物。是一种选择性5-HT_1A 受体沉默拮抗剂。^[1]结构上与8-OH-DPAT相似。^[1] UH-301会令小鼠产生头部抽搐反应，是5-HT_2A激动剂药物的典型反应，因此可用来研究5-HT_1A受体活性如何调节下游5-HT_2A受体。^[2]

参见

参考文献

^ ^1.0 ^1.1 Pharmacology of the novel 5-hydroxytryptamine1A receptor antagonist (S)-5-fluoro-8-hydroxy-2-(dipropylamino)tetralin: inhibition of (R)-8-hydroxy-2-(dipropylamino)tetralin-induced effects.. J Pharmacol Exp Ther. 1991, 258 (1): 58–65. PMID 1830099.
^ Darmani, N. A.; Reeves, S. L. The mechanism by which the selective 5-HT1A receptor antagonist S-(-) UH 301 produces head-twitches in mice. Pharmacology Biochemistry and Behavior. 1996, 55 (1): 1–10. PMID 8870031. doi:10.1016/0091-3057(96)00072-X.

[pmid1830099-1] 1.0 ^1.1 Pharmacology of the novel 5-hydroxytryptamine1A receptor antagonist (S)-5-fluoro-8-hydroxy-2-(dipropylamino)tetralin: inhibition of (R)-8-hydroxy-2-(dipropylamino)tetralin-induced effects.. J Pharmacol Exp Ther. 1991, 258 (1): 58–65. PMID 1830099.

[2] Darmani, N. A.; Reeves, S. L. The mechanism by which the selective 5-HT1A receptor antagonist S-(-) UH 301 produces head-twitches in mice. Pharmacology Biochemistry and Behavior. 1996, 55 (1): 1–10. PMID 8870031. doi:10.1016/0091-3057(96)00072-X.

[1]

[2]

识别信息


IUPAC命名法 (S)-5-fluoro-8-hydroxy-2-(dipropylamino)tetralin
CAS号	127126-22-1 ^Y
IUPHAR/BPS	61
UNII	1T7773JH5N
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)	DTXSID70155410
化学信息
化学式	C₁₆H₂₄FNO
摩尔质量	265.37 g·mol⁻¹
3D模型（JSmol（英语：JSmol））	交互式图像
SMILES C2Cc1c(c(O)ccc1F)CC2N(CCC)CCC