丝裂霉素C

丝裂霉素C(英语:Mitomycin C)是化疗药物丝裂霉素的一种,分子式C15H18N4O5,1950年代由日本科学家在链霉菌属Streptomyces caespitosus中发现[5]

丝裂霉素C
临床资料
商品名英语Drug nomenclatureMitosol, Mutamycin, Jelmyto
其他名称UGN-101
AHFS/Drugs.comMonograph
MedlinePlusa682415
核准状况
怀孕分级
给药途径静脉注射外用
药物类别英语Drug class抗肿瘤药
ATC码
法律规范状态
法律规范
药物动力学数据
药物代谢肝脏
生物半衰期8–48 min
识别信息
  • {11-Amino-7-methoxy-12-methyl-10,13-dioxo-2,5-diazatetracyclo[7.4.0.02,7.04,6]trideca-1(9),11-dien-8-yl}methyl carbamate
CAS号50-07-7
PubChem CID
PubChem SID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
ECHA InfoCard100.000.008 编辑维基数据链接
化学信息
化学式C15H18N4O5
摩尔质量334.33 g·mol−1
3D模型(JSmol英语JSmol
熔点360 °C(680 °F)
水溶性8.43 g L−1
  • CO[C@@]12[C@H](COC(N)=O)C3=C(C(=O)C(C)=C(N)C3=O)N1C[C@@H]1N[C@@H]12
  • InChI=1S/C15H18N4O5/c1-5-9(16)12(21)8-6(4-24-14(17)22)15(23-2)13-7(18-13)3-19(15)10(8)11(5)20/h6-7,13,18H,3-4,16H2,1-2H3,(H2,17,22)/t6-,7+,13+,15-/m1/s1 checkY
  • Key:NWIBSHFKIJFRCO-WUDYKRTCSA-N

参考文献

  1. ^ Reiss, G.J. KUWQIF: Mitomycin C Dihydrate, also known as (6-amino-8a-methoxy-5-methyl-4,7-dioxo-1,1a,2,4,7,8,8a,8b-octahydroazireno[2',3':3,4]pyrrolo[1,2-a]indol-8-yl)methyl carbamate dihydrate. Cambridge Structural Database: Access Structures (Cambridge Crystallographic Data Centre). 2011 [2021-11-03]. doi:10.5517/ccdc.csd.cc12bt29. (原始内容存档于19 November 2021). 
  2. ^ Mitomycin (Mutamycin) Use During Pregnancy. Drugs.com. 19 August 2019 [15 April 2020]. (原始内容存档于22 October 2020). 
  3. ^ Mitocin mitomycin 20 mg powder for injection vial (370360). Therapeutic Goods Administration (TGA). 12 August 2022 [29 April 2023]. (原始内容存档于18 March 2023). 
  4. ^ Mitocin (Echo Therapeutics Pty Ltd). Therapeutic Goods Administration (TGA). 28 September 2022 [29 April 2023]. (原始内容存档于18 March 2023). 
  5. ^ Tomasz M. Mitomycin C: small, fast and deadly (but very selective). Chemistry & Biology. September 1995, 2 (9): 575–579. PMID 9383461. doi:10.1016/1074-5521(95)90120-5 . 

外部链接

  • Clinical trial number NCT02793128 for "The OLYMPUS Study - Optimized DeLivery of Mitomycin for Primary UTUC Study (Olympus)" at ClinicalTrials.gov