初始B细胞

初始B细胞(naive B cell / virgin B cell)系一类还未与抗原接触的B细胞。一旦与抗原接触,它就会增殖分化为记忆B细胞或者能产生能与刺激它的抗原特异性结合的抗体浆细胞。与寿命不长的浆细胞不同,记忆B细胞不能产生抗体,但能够长期存活,并能在同种抗原再次入侵时,迅速增殖分化为能产生大量抗体的浆细胞和新的记忆细胞[1][2]

参考

  1. ^ Airoldi I, Raffaghello L, Cocco C; et al. Heterogeneous expression of interleukin-18 and its receptor in B-cell lymphoproliferative disorders deriving from naive, germinal center, and memory B lymphocytes. Clin. Cancer Res. January 2004, 10 (1 Pt 1): 144–54 [2014-12-06]. PMID 14734463. doi:10.1158/1078-0432.CCR-1026-3. (原始内容存档于2016-12-20). 
  2. ^ Lang ML. How do natural killer T cells help B cells?. Expert Rev Vaccines. Aug 2009, 8 (8): 1109–21. PMC 2747240 . PMID 19627191. doi:10.1586/erv.09.56.