CD1a （C luster of D ifferentiation 1a ）是身上的一种人类蛋白质 ，由基因“CD1A [ 3]
该蛋白属于CD1蛋白家族 ，为一种穿膜糖蛋白。CD1a与β2-微球蛋白 共同构成的异源二聚体（heterodimers）称为“CD1a复合体”（CD1a complex），在结构上类似MHC I分子 。两者都具有抗原呈现 的能力，但CD1a主要呈现的是糖脂类 ，而MHC分子主要呈现的是多肽类 。人类身上的CD1家族基因共有五个，且都集中排列在1号染色体 上的某个区域[ 3]
在抽烟的病人身上，“CD1A ”在肺间质的表现会较为显著[ 4]
^ 1.0 1.1 1.2 GRCh38: Ensembl release 89: ENSG00000158477 - Ensembl , May 2017^ Human PubMed Reference: . National Center for Biotechnology Information, U.S. National Library of Medicine. ^ 3.0 3.1 Entrez Gene: CD1A CD1a molecule . ^ Pintarelli G, Noci S, Maspero D, Pettinicchio A, Dugo M, De Cecco L, Incarbone M, Tosi D, Santambrogio L, Dragani TA, Colombo F. Cigarette smoke alters the transcriptome of non-involved lung tissue in lung adenocarcinoma patients . Scientific Reports. September 2019, 9 (1): 13039. Bibcode:2019NatSR...913039P PMC 6736939 PMID 31506599 doi:10.1038/s41598-019-49648-2
Melián A, Beckman EM, Porcelli SA, Brenner MB. Antigen presentation by CD1 and MHC-encoded class I-like molecules.. Curr. Opin. Immunol. 1996, 8 (1): 82–8. PMID 8729450 doi:10.1016/S0952-7915(96)80109-9 Park SH, Bendelac A. CD1-restricted T-cell responses and microbial infection.. Nature. 2000, 406 (6797): 788–92. PMID 10963609 S2CID 4373172 doi:10.1038/35021233 Brigl M, Brenner MB. CD1: antigen presentation and T cell function.. Annu. Rev. Immunol. 2004, 22 (1): 817–90. PMID 15032598 doi:10.1146/annurev.immunol.22.012703.104608 Coventry B, Heinzel S. CD1a in human cancers: a new role for an old molecule. . Trends Immunol. 2004, 25 (5): 242–8. PMID 15099564 doi:10.1016/j.it.2004.03.002 Moody DB, Zajonc DM, Wilson IA. Anatomy of CD1-lipid antigen complexes.. Nat. Rev. Immunol. 2005, 5 (5): 387–99. PMID 15864273 S2CID 1387491 doi:10.1038/nri1605 Stove V, Verhasselt B. Modelling thymic HIV-1 Nef effects.. Curr. HIV Res. 2006, 4 (1): 57–64. PMID 16454711 doi:10.2174/157016206775197583 Quaranta MG, Mattioli B, Giordani L, Viora M. The immunoregulatory effects of HIV-1 Nef on dendritic cells and the pathogenesis of AIDS. . FASEB J. 2006, 20 (13): 2198–208. PMID 17077296 S2CID 3111709 doi:10.1096/fj.06-6260rev Oakey RJ, Watson ML, Seldin MF. Construction of a physical map on mouse and human chromosome 1: comparison of 13 Mb of mouse and 11 Mb of human DNA.. Hum. Mol. Genet. 1993, 1 (8): 613–20. PMID 1301170 doi:10.1093/hmg/1.8.613 Martin LH, Calabi F, Lefebvre FA, et al. Structure and expression of the human thymocyte antigens CD1a, CD1b, and CD1c. . Proc. Natl. Acad. Sci. U.S.A. 1988, 84 (24): 9189–93. PMC 299718 PMID 2447586 doi:10.1073/pnas.84.24.9189 Moseley WS, Watson ML, Kingsmore SF, Seldin MF. CD1 defines conserved linkage group border between human chromosomes 1 and mouse chromosomes 1 and 3. . Immunogenetics. 1989, 30 (5): 378–82. PMID 2478463 S2CID 9361881 doi:10.1007/BF02425278 Yu CY, Milstein C. A physical map linking the five CD1 human thymocyte differentiation antigen genes. . EMBO J. 1990, 8 (12): 3727–32. PMC 402056 PMID 2583117 doi:10.1002/j.1460-2075.1989.tb08548.x Aruffo A, Seed B. Expression of cDNA clones encoding the thymocyte antigens CD1a, b, c demonstrates a hierarchy of exclusion in fibroblasts.. J. Immunol. 1989, 143 (5): 1723–30. PMID 2701945 S2CID 23168239 doi:10.4049/jimmunol.143.5.1723 Longley J, Kraus J, Alonso M, Edelson R. Molecular cloning of CD1a (T6), a human epidermal dendritic cell marker related to class I MHC molecules. . J. Invest. Dermatol. 1989, 92 (4): 628–31. PMID 2784820 doi:10.1111/1523-1747.ep12712175 Albertson DG, Fishpool R, Sherrington P, et al. Sensitive and high resolution in situ hybridization to human chromosomes using biotin labelled probes: assignment of the human thymocyte CD1 antigen genes to chromosome 1. . EMBO J. 1988, 7 (9): 2801–5. PMC 457071 PMID 3053166 doi:10.1002/j.1460-2075.1988.tb03135.x Calabi F, Milstein C. A novel family of human major histocompatibility complex-related genes not mapping to chromosome 6.. Nature. 1986, 323 (6088): 540–3. Bibcode:1986Natur.323..540C PMID 3093894 S2CID 4274219 doi:10.1038/323540a0 Martin LH, Calabi F, Milstein C. Isolation of CD1 genes: a family of major histocompatibility complex-related differentiation antigens. . Proc. Natl. Acad. Sci. U.S.A. 1987, 83 (23): 9154–8. PMC 387093 PMID 3097645 doi:10.1073/pnas.83.23.9154 Woolfson A, Milstein C. Alternative splicing generates secretory isoforms of human CD1. . Proc. Natl. Acad. Sci. U.S.A. 1994, 91 (14): 6683–7. Bibcode:1994PNAS...91.6683W PMC 44267 PMID 7517559 doi:10.1073/pnas.91.14.6683 Han M, Hannick LI, DiBrino M, Robinson MA. Polymorphism of human CD1 genes. . Tissue Antigens. 2000, 54 (2): 122–7 [2023-06-03 ] . PMID 10488738 doi:10.1034/j.1399-0039.1999.540202.x 存档 于2023-04-11）. Sugita M, Grant EP, van Donselaar E, et al. Separate pathways for antigen presentation by CD1 molecules.. Immunity. 2000, 11 (6): 743–52. PMID 10626896 doi:10.1016/S1074-7613(00)80148-X
CD1A 引用了美国国家医学图书馆 提供的数据，这些数据属于公共领域 。
. PMID 31506599. doi:10.1038/s41598-019-49648-2.
