Pho4是一种在酿酒酵母S. cerevisiae)中发现的碱性螺旋-环-螺旋(bHLH)转录因子,在其它酵母中也有发现[2]

Pho4
Crystallographic structure of yeast Pho4 homodimer (cyan and green) complexed with DNA (brown).[1]
标识
生物 ?
符号 Pho4
可选符号 YFR034C
Entrez 850594
PDB 1a0a
UniProt P07270
其他数据

Pho4蛋白形成同源二聚体后进入细胞核结合DNA,其识别位点为:5'-CACGTG-3'[3],这一序列常出现在Pho5磷酸酶基因启动子区域[4]

参考文献

  1. ^ PDB 1a0a; Shimizu T, Toumoto A, Ihara K, Shimizu M, Kyogoku Y, Ogawa N, Oshima Y, Hakoshima T. Crystal structure of PHO4 bHLH domain-DNA complex: flanking base recognition. EMBO J. August 1997, 16 (15): 4689–97. PMC 1170095 . PMID 9303313. doi:10.1093/emboj/16.15.4689. 
  2. ^ Berben G, Legrain M, Gilliquet V, Hilger F. The yeast regulatory gene PHO4 encodes a helix-loop-helix motif. Yeast. 1990, 6 (5): 451–4. PMID 2220078. doi:10.1002/yea.320060510. 
  3. ^ Shao D, Creasy CL, Bergman LW. A cysteine residue in helixII of the bHLH domain is essential for homodimerization of the yeast transcription factor Pho4p. Nucleic Acids Res. February 1998, 26 (3): 710–4. PMC 147311 . PMID 9443961. doi:10.1093/nar/26.3.710. 
  4. ^ Ogawa N, Oshima Y. Functional domains of a positive regulatory protein, PHO4, for transcriptional control of the phosphatase regulon in Saccharomyces cerevisiae. Mol. Cell. Biol. May 1990, 10 (5): 2224–36. PMC 360570 . PMID 2183025. doi:10.1128/mcb.10.5.2224. 

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