依普罗醇

依普罗醇(英语:Eprozinol)是一种含氮有机化合物,化学式C22H30N2O2,能作为阻塞性肺病的药物[1][2]

依普罗醇
IUPAC名
3-[4-(2-Methoxy-2-phenylethyl)piperazin-1-yl]-1-phenylpropan-1-ol
识别
CAS号 32665-36-4  checkY
PubChem 122553
ChemSpider 109268
SMILES
 
  • COC(CN1CCN(CC1)CCC(C2=CC=CC=C2)O)C3=CC=CC=C3
KEGG D07379
性质
化学式 C22H30N2O2
摩尔质量 354.4858 g·mol⁻¹
药理学
ATC代码 R03DX02R03
若非注明,所有数据均出自标准状态(25 ℃,100 kPa)下。

合成

(-)-(R,S)-依普罗醇可由2-氯苯乙酮N-苄基哌嗪和(S)-3-氯-1-苯基-1-丙醇为原料,经多步反应制得。[3]

参考文献

  1. ^ Nicrosini, F.; Carpinella, G. Eprozinol treatment of chronic bronchitis with dyspnea and cough. Broncho-pneumologie. 1978, 28 (4): 322–327. PMID 756799. 
  2. ^ Labrid, C.; Duchene-Marullaz, P.; Rispat, G. Mechanisms of anti-bronchoconstrictive effects of eprozinol. II. In vivo studies on the guinea pig. Pharmacology. 1981, 23 (1): 48–55. PMID 7312935. doi:10.1159/000137526. 
  3. ^ P. Veeraraghavan Ramachandran, Baoqing Gong, Herbert C. Brown. Chiral synthesis via organoboranes. 41. The utility of B-chlorodiisopinocampheylborane for a general synthesis of enantiomerically pure drugs. Chirality. 1995. 7 (2). 103-110. doi:10.1002/chir.530070209.

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