氯噻嗪(化学式:C7H6ClN3O4S2)是一种有机化合物,可用作利尿剂抗高血压药[1][2]

氯噻嗪
临床资料
商品名英语Drug nomenclatureDiuril, others
其他名称6-Chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide-1,1-dioxide
AHFS/Drugs.comMonograph
MedlinePlusa682341
给药途径By mouth, IV
ATC码
法律规范状态
法律规范
药物动力学数据
生物利用度low
药物代谢Nil
生物半衰期45 to 120 minutes
排泄途径Renal
识别信息
  • 6-chloro-1,1-dioxo-2H-1,2,4-benzothiadiazine-7-sulfonamide
CAS号58-94-6  checkY
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
ECHA InfoCard100.000.368 编辑维基数据链接
化学信息
化学式C7H6ClN3O4S2
摩尔质量295.71 g·mol−1
3D模型(JSmol英语JSmol
熔点342.5—343 °C(648.5—649.4 °F)
  • O=S(=O)(c1c(Cl)cc2c(c1)S(=O)(=O)/N=C\N2)N
  • InChI=1S/C7H6ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-3H,(H,10,11)(H2,9,12,13) checkY
  • Key:JBMKAUGHUNFTOL-UHFFFAOYSA-N checkY

它于1956年获得专利,并于1958年被批准用于医疗。[3]它是世界卫生组织基本药物标准清单上的药物。[4]

参考文献

  1. ^ Ernst ME, Grimm J, Richard H. Thiazide diuretics: 50 years and beyond.. Current Hypertension Reviews. November 2008, 4 (4): 256–65. doi:10.2174/157340208786241264. 
  2. ^ Duarte JD, Cooper-DeHoff RM. Mechanisms for blood pressure lowering and metabolic effects of thiazide and thiazide-like diuretics. Expert Review of Cardiovascular Therapy. June 2010, 8 (6): 793–802. PMC 2904515 . PMID 20528637. doi:10.1586/erc.10.27. 
  3. ^ Fischer J, Ganellin CR. Analogue-based Drug Discovery. John Wiley & Sons. 2006: 456. ISBN 9783527607495 (英语). 
  4. ^ World Health Organization. World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. 2021. hdl:10665/345533 . WHO/MHP/HPS/EML/2021.02. 

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