JWH-073

化合物

JWH-073,化学名N-正丁基-3-(1-萘甲酰基)吲哚,分子式C23H21NO,属于甲酰基吲哚JWH系列大麻素,是大麻素受体CB1和CB2的全激动剂[3],由约翰·威廉·霍夫曼小组合成[4]

JWH-073
法律规范状态
法律规范
识别信息
  • Naphthalen-1-yl-(1-butylindol-3-yl)methanone
CAS号208987-48-8  checkY
PubChem CID
ChemSpider
UNII
KEGG
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
ECHA InfoCard100.230.192 编辑维基数据链接
化学信息
化学式C23H21NO
摩尔质量327.43 g·mol−1
3D模型(JSmol英语JSmol
  • CCCCN1C=C(C2=CC=CC=C21)C(=O)C3=CC=CC4=CC=CC=C43
  • InChI=1S/C23H21NO/c1-2-3-15-24-16-21(19-12-6-7-14-22(19)24)23(25)20-13-8-10-17-9-4-5-11-18(17)20/h4-14,16H,2-3,15H2,1H3 ☒N
  • Key:VCHHHSMPMLNVGS-UHFFFAOYSA-N ☒N

参考文献

  1. ^ Grozījumi Ministru kabineta 2005.gada 8.novembra noteikumos Nr.847 "Noteikumi par Latvijā kontrolējamajām narkotiskajām vielām, psihotropajām vielām un prekursoriem". Legal Acts of the Republic of Latvia. [2024-01-29]. (原始内容存档于2010-09-14) (Latvian). 
  2. ^ Anvisa. RDC Nº 804 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial [Collegiate Board Resolution No. 804 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control]. Diário Oficial da União. 2023-07-24 (2023-07-25) [2023-08-27]. (原始内容存档于2023-08-27) (巴西葡萄牙语). 
  3. ^ Lisa K. Brents, Anna Gallus-Zawada, Anna Radominska-Pandya, Tamara Vasiljevik, Thomas E Prisinzano, William E Fantegrossi, Jeffery H Moran, Paul L Prather. Monohydroxylated metabolites of the K2 synthetic cannabinoid JWH-073 retain intermediate to high cannabinoid 1 receptor (CB1R) affinity and exhibit neutral antagonist to partial agonist activity. Biochemical Pharmacology. 2012, 83 (7): 952–961 [2024-01-29]. PMID 22266354. doi:10.1016/j.bcp.2012.01.004. hdl:1808/22684 . (原始内容存档于2023-10-31). JWH-073 displays equivalent efficacy to that of the CB1R full agonist CP-55,940 
  4. ^ Aung MM, Griffin G, Huffman JW, Wu M, Keel C, Yang B, Showalter VM, Abood ME, Martin BR. Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB1 and CB2)receptor binding. Drug Alcohol Depend. August 2000, 60 (2): 133–40. PMID 10940540. doi:10.1016/S0376-8716(99)00152-0. 

外部链接