CTLA4又稱CTLA-4(細胞毒性T淋巴細胞相關抗原4,cytotoxic T-lymphocyte-associated protein 4)或CD152分化群152),是一種蛋白質受體[7]。CTLA-4蛋白由小鼠的Ctla4[8]和人類的CTLA4基因編碼[9]。CTLA-4於1991年首次被發現[10]

細胞毒性T淋巴細胞相關抗原4
已知的結構
PDB直系同源搜索: PDBe RCSB
識別號
別名CTLA4;, ALPS5, CD, CD152, CELIAC3, CTLA-4, GRD4, GSE, IDDM12, cytotoxic T-lymphocyte associated protein 4
外部IDOMIM123890 MGI88556 HomoloGene3820 GeneCardsCTLA4
相關疾病
類風濕性關節炎、​甲狀腺機能低下症、​1型糖尿病、​type 1 diabetes mellitus 12、​autoimmune lymphoproliferative syndrome due to CTLA4 haploinsuffiency[1]
為以下藥物的標靶
伊匹單抗[2]
基因位置(人類
2號染色體
染色體2號染色體[3]
2號染色體
細胞毒性T淋巴細胞相關抗原4的基因位置
細胞毒性T淋巴細胞相關抗原4的基因位置
基因座2q33.2起始203,853,888 bp[3]
終止203,873,965 bp[3]
RNA表達模式
查閱更多表達數據
直系同源
物種人類小鼠
Entrez
Ensembl
UniProt
mRNA​序列

NM_001037631
​NM_005214

NM_001281976
​NM_009843

蛋白序列

NP_001032720
​NP_005205

NP_001268905
​NP_033973

基因位置​(UCSC)Chr 2: 203.85 – 203.87 MbChr 1: 60.93 – 60.95 Mb
PubMed​查找[5][6]
維基數據
檢視/編輯人類檢視/編輯小鼠

參考文獻

  1. ^ 與細胞毒性T淋巴細胞相關抗原4相關的疾病;在維基數據上查看/編輯參考. 
  2. ^ 對細胞毒性T淋巴細胞相關抗原4起作用的藥物;在維基數據上查看/編輯參考. 
  3. ^ 3.0 3.1 3.2 GRCh38: Ensembl release 89: ENSG00000163599 - Ensembl, May 2017
  4. ^ 4.0 4.1 4.2 GRCm38: Ensembl release 89: ENSMUSG00000026011 - Ensembl, May 2017
  5. ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  6. ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  7. ^ De-novo and acquired resistance to immune checkpoint targeting. The Lancet. Oncology. December 2017, 18 (12): e731–e741. PMID 29208439. doi:10.1016/s1470-2045(17)30607-1. 
  8. ^ A new member of the immunoglobulin superfamily--CTLA-4. Nature. 1987, 328 (6127): 267–70. Bibcode:1987Natur.328..267B. PMID 3496540. doi:10.1038/328267a0. 
  9. ^ Human Ig superfamily CTLA-4 gene: chromosomal localization and identity of protein sequence between murine and human CTLA-4 cytoplasmic domains. European Journal of Immunology. December 1988, 18 (12): 1901–5. PMID 3220103. doi:10.1002/eji.1830181206. 
  10. ^ Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. Science. November 1995, 270 (5238): 985–8. Bibcode:1995Sci...270..985W. JSTOR 2888113. PMID 7481803. doi:10.1126/science.270.5238.985.