CXCL10(英語:C-X-C motif chemokine 10)是一小分子的細胞因子屬於CXC趨化因子家族[5],又被稱作「干擾素伽瑪誘導的10千道爾頓蛋白」(10 kDa interferon-gamma-induced protein,IP-10)[6]干擾素伽瑪可以在多種細胞(如巨噬細胞[7]單核細胞[7]內皮細胞[8]成纖維細胞)中誘導CXCL10的表達。CXCL10的功能包括對T細胞和單核細胞的細胞趨化作用[9][10],促進T細胞黏附於內皮細胞[8],抗腫瘤[11],及血管新生[8]。人類的CXCL10基因與CXCL9CXCL11的基因相鄰聚集在第四染色體上。CXCL10, CXCL9和CXCL11結合趨化因子受體CXCR3而起其細胞趨化作用[9][10]

CXCL10
已知的結構
PDB直系同源搜索: PDBe RCSB
識別號
別名CXCL10;, C7, IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1, C-X-C motif chemokine ligand 10, C-X-C motif chemokine 10
外部IDOMIM147310 MGI1352450 HomoloGene1203 GeneCardsCXCL10
基因位置(人類
4號染色體
染色體4號染色體[1]
4號染色體
CXCL10的基因位置
CXCL10的基因位置
基因座4q21.1起始76,021,118 bp[1]
終止76,023,497 bp[1]
RNA表達模式
查閱更多表達數據
直系同源
物種人類小鼠
Entrez
Ensembl
UniProt
mRNA​序列

NM_001565

NM_021274

蛋白序列

NP_001556

NP_067249

基因位置​(UCSC)Chr 4: 76.02 – 76.02 MbChr 5: 92.49 – 92.5 Mb
PubMed​查找[3][4]
維基數據
檢視/編輯人類檢視/編輯小鼠

參見

參考文獻

  1. ^ 1.0 1.1 1.2 GRCh38: Ensembl release 89: ENSG00000169245 - Ensembl, May 2017
  2. ^ 2.0 2.1 2.2 GRCm38: Ensembl release 89: ENSMUSG00000034855 - Ensembl, May 2017
  3. ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  4. ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  5. ^ Liu L, Callahan MK, Huang D, Ransohoff RM. Chemokine receptor CXCR3: an unexpected enigma. Curr Top Dev Biol. 2005;68:149-81.
  6. ^ Kaplan G, Luster AD, Hancock G, Cohn ZA. The expression of a gamma interferon-induced protein (IP-10) in delayed immune responses in human skin. J Exp Med. 1987 Oct 1;166(4):1098-108.
  7. ^ 7.0 7.1 Narumi S, Hamilton TA. Inducible expression of murine IP-10 mRNA varies with the state of macrophage inflammatory activity. J Immunol. 1991 May 1;146(9):3038-44.
  8. ^ 8.0 8.1 8.2 Angiolillo AL, Sgadari C, Taub DD, Liao F, Farber JM, Maheshwari S, Kleinman HK, Reaman GH, Tosato G. Human interferon-inducible protein 10 is a potent inhibitor of angiogenesis in vivo. J Exp Med. 1995 Jul 1;182(1):155-62.
  9. ^ 9.0 9.1 Loetscher M, Gerber B, Loetscher P, Jones SA, Piali L, Clark-Lewis I, Baggiolini M, Moser B. Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes. J Exp Med. 1996 Sep 1;184(3):963-9.
  10. ^ 10.0 10.1 Weng Y, Siciliano SJ, Waldburger KE, Sirotina-Meisher A, Staruch MJ, Daugherty BL, Gould SL, Springer MS, DeMartino JA. Binding and functional properties of recombinant and endogenous CXCR3 chemokine receptors. J Biol Chem. 1998 Jul 17;273(29):18288-91.
  11. ^ Luster AD, Leder P. IP-10, a -C-X-C- chemokine, elicits a potent thymus-dependent antitumor response in vivo. J Exp Med. 1993 Sep 1;178(3):1057-65

外部連結