趨化因子CXCL7(英語:Chemokine (C-X-C motif) ligand 7,CXCL7)是一個人類基因[1]。其編碼的蛋白質為趨化因子(C-X-C基序)配體7 Chemokine (C-X-C motif) ligand,是一種CXC趨化因子細胞因子,其蛋白異型體為β-血小板球蛋白或原血小板鹼性蛋白(英語:Pro-Platelet basic protein,PPBP)[2]

Pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PDB rendering based on 1f9p.
有效結構
PDB 直系同源檢索:PDBe, RCSB
標識
代號 PPBP; B-TG1; Beta-TG; CTAP-III; CTAP3; CTAPIII; CXCL7; LA-PF4; LDGF; MDGF; NAP-2; PBP; SCYB7; TC1; TC2; TGB; TGB1; THBGB; THBGB1
擴展標識 遺傳學121010 鼠基因1888712 同源基因48122 GeneCards: PPBP Gene
RNA表達模式
更多表達數據
直系同源體
物種 人類 小鼠
Entrez 5473 57349
Ensembl ENSG00000163736 ENSMUSG00000029372
UniProt P02775 Q9EQI5
mRNA序列 NM_002704 NM_023785
蛋白序列 NP_002695 NP_076274
基因位置 Chr 4:
74.85 – 74.85 Mb
Chr 5:
90.77 – 90.77 Mb
PubMed查詢 [1] [2]

這種蛋白在血小板活化時被大量釋放[3] ,能刺激多種過程,包括有絲分裂細胞外基質的合成、糖代謝英語glucose metabolism纖溶酶原激活物的合成[4][5]

參考文獻

  1. ^ Entrez Gene: PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7). (原始內容存檔於2019-09-24). 
  2. ^ Hristov M, Zernecke A, Bidzhekov K; et al. Importance of CXC chemokine receptor 2 in the homing of human peripheral blood endothelial progenitor cells to sites of arterial injury. Circ. Res. March 2007, 100 (4): 590–7. PMID 17272812. doi:10.1161/01.RES.0000259043.42571.68. 
  3. ^ Majumdar S, Gonder D, Koutsis B, Poncz M. Characterization of the human beta-thromboglobulin gene. Comparison with the gene for platelet factor 4. J Biol Chem. 1991, 266 (9): 5785–9. PMID 1826003. 
  4. ^ Castor C, Miller J, Walz D. Structural and biological characteristics of connective tissue activating peptide (CTAP-III), a major human platelet-derived growth factor. Proc Natl Acad Sci USA. 1983, 80 (3): 765–9. PMC 393460 . PMID 6572368. doi:10.1073/pnas.80.3.765. 
  5. ^ Castor C, Furlong A, Carter-Su C. Connective tissue activation: stimulation of glucose transport by connective tissue activating peptide III. Biochemistry. 1985, 24 (7): 1762–7. PMID 4005226. doi:10.1021/bi00328a029. 

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