維基百科

STAT1

位於2號人類染色體的基因

STAT1是轉錄因子中信號轉導及轉錄激活蛋白（STAT蛋白）家族的一員。

STAT1
已知的結構
PDB直系同源搜索: PDBe RCSB
識別號
別名STAT1；, CANDF7, IMD31A, IMD31B, IMD31C, ISGF-3, STAT91, signal transducer and activator of transcription 1
外部IDOMIM：600555 MGI：103063 HomoloGene：21428 GeneCards：STAT1
相關疾病
慢性黏膜皮膚念珠菌病、​susceptibility to viral and mycobacterial infections[1]
基因位置（人類）
2號染色體
染色體2號染色體[2]
2號染色體
STAT1的基因位置
STAT1的基因位置
基因座2q32.2起始190,908,460 bp[2]
終止191,020,960 bp[2]
RNA表達模式
查閱更多表達數據
直系同源
物種人類小鼠
Entrez

6772

20846

Ensembl

ENSG00000115415

ENSMUSG00000026104

UniProt

P42224

P42225

mRNA​序列

​NM_007315
​NM_139266

NM_001205313
​NM_001205314
​NM_009283
​NM_001357627

蛋白序列

NP_009330
​NP_644671

無數據

基因位置​（UCSC）Chr 2: 190.91 – 191.02 MbChr 1: 52.16 – 52.2 Mb
PubMed​查找[4][5]
維基數據
檢視/編輯人類檢視/編輯小鼠

STAT1涉及I型、II型或III型干擾素激活基因的正調控。在干擾素-γ刺激下，STAT1會組成同源二聚體或與STAT3組成異二聚體結合到GAS（Interferon-Gamma-Activated Sequence，干擾素γ激活序列）啟動子上；而在干擾素-α或干擾素-β刺激下，STAT1會與STAT2組成異二聚體結合到ISRE（Interferon-Stimulated Response Element，干擾素激活反應元件）啟動子上[6]。在這兩種情況下，STAT二聚體與啟動子的結合都會導致ISG（Interferon-Stimulated Genes，干擾素激活基因）的表達。

STAT1可由二烯丙基二硫誘導表達[7]

相互作用

STAT1能與下列蛋白質發生相互作用：

參考文獻

  1. ^ 與STAT1相關的疾病；在維基數據上查看/編輯參考. 
  2. ^ 2.0 2.1 2.2 GRCh38: Ensembl release 89: ENSG00000115415 - Ensembl, May 2017
  3. ^ 3.0 3.1 3.2 GRCm38: Ensembl release 89: ENSMUSG00000026104 - Ensembl, May 2017
  4. ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  5. ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  6. ^ Michael G. Katze; Yupeng He & Michael Gale; et al. Viruses and interferon: a fight for supremacy. Nature Reviews Immunology. 2002, 2 (9): 675–87. PMID 12209136. doi:10.1038/nri888. 
  7. ^ Lu HF, Yang JS, Lin YT, Tan TW, Ip SW, Li YC, Tsou MF, Chung JG. Diallyl disulfide induced signal transducer and activator of transcription 1 expression in human colon cancer colo 205 cells using differential display RT-PCR. Cancer Genomics Proteomics. 2007, 4 (2): 93–7. PMID 17804871. 
  8. ^ Wong, A H; Tam N W, Yang Y L, Cuddihy A R, Li S, Kirchhoff S, Hauser H, Decker T, Koromilas A E. Physical association between STAT1 and the interferon-inducible protein kinase PKR and implications for interferon and double-stranded RNA signaling pathways. EMBO J. (ENGLAND). March 1997, 16 (6): 1291–304. ISSN 0261-4189. PMC 1169727  . PMID 9135145. doi:10.1093/emboj/16.6.1291. 
  9. ^ Wong, A H; Durbin J E, Li S, Dever T E, Decker T, Koromilas A E. Enhanced antiviral and antiproliferative properties of a STAT1 mutant unable to interact with the protein kinase PKR. J. Biol. Chem. (United States). April 2001, 276 (17): 13727–37. ISSN 0021-9258. PMID 11278865. doi:10.1074/jbc.M011240200. 
  10. ^ 10.0 10.1 Olayioye, M A; Beuvink I, Horsch K, Daly J M, Hynes N E. ErbB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinases. J. Biol. Chem. (United States). June 1999, 274 (24): 17209–18. ISSN 0021-9258. PMID 10358079. doi:10.1074/jbc.274.24.17209. 
  11. ^ Cirri, P; Chiarugi P, Marra F, Raugei G, Camici G, Manao G, Ramponi G. c-Src activates both STAT1 and STAT3 in PDGF-stimulated NIH3T3 cells. Biochem. Biophys. Res. Commun. (United States). October 1997, 239 (2): 493–7. ISSN 0006-291X. PMID 9344858. doi:10.1006/bbrc.1997.7493. 
  12. ^ Chatterjee-Kishore, M; van Den Akker F, Stark G R. Adenovirus E1A down-regulates LMP2 transcription by interfering with the binding of stat1 to IRF1. J. Biol. Chem. (United States). July 2000, 275 (27): 20406–11. ISSN 0021-9258. PMID 10764778. doi:10.1074/jbc.M001861200. 
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  14. ^ Spiekermann, K; Biethahn S, Wilde S, Hiddemann W, Alves F. Constitutive activation of STAT transcription factors in acute myelogenous leukemia. Eur. J. Haematol. (Denmark). August 2001, 67 (2): 63–71. ISSN 0902-4441. PMID 11722592. 
  15. ^ 15.0 15.1 Xia, Ling; Wang Lijuan, Chung Alicia S, Ivanov Stanimir S, Ling Mike Y, Dragoi Ana M, Platt Adam, Gilmer Tona M, Fu Xin-Yuan, Chin Y Eugene. Identification of both positive and negative domains within the epidermal growth factor receptor COOH-terminal region for signal transducer and activator of transcription (STAT) activation. J. Biol. Chem. (United States). August 2002, 277 (34): 30716–23. ISSN 0021-9258. PMID 12070153. doi:10.1074/jbc.M202823200. 
  16. ^ Zhang, J J; Zhao Y, Chait B T, Lathem W W, Ritzi M, Knippers R, Darnell J E. Ser727-dependent recruitment of MCM5 by Stat1alpha in IFN-gamma-induced transcriptional activation. EMBO J. (ENGLAND). Dec 1998, 17 (23): 6963–71. ISSN 0261-4189. PMC 1171044  . PMID 9843502. doi:10.1093/emboj/17.23.6963. 
  17. ^ DaFonseca, C J; Shu F, Zhang J J. Identification of two residues in MCM5 critical for the assembly of MCM complexes and Stat1-mediated transcription activation in response to IFN-gamma. Proc. Natl. Acad. Sci. U.S.A. (United States). March 2001, 98 (6): 3034–9. ISSN 0027-8424. PMC 30602  . PMID 11248027. doi:10.1073/pnas.061487598. 
  18. ^ Li, X; Leung S, Qureshi S, Darnell J E, Stark G R. Formation of STAT1-STAT2 heterodimers and their role in the activation of IRF-1 gene transcription by interferon-alpha. J. Biol. Chem. (United States). March 1996, 271 (10): 5790–4. ISSN 0021-9258. PMID 8621447. doi:10.1074/jbc.271.10.5790. 
  19. ^ Dumler, I; Kopmann A, Wagner K, Mayboroda O A, Jerke U, Dietz R, Haller H, Gulba D C. Urokinase induces activation and formation of Stat4 and Stat1-Stat2 complexes in human vascular smooth muscle cells. J. Biol. Chem. (United States). August 1999, 274 (34): 24059–65. ISSN 0021-9258. PMID 10446176. doi:10.1074/jbc.274.34.24059. 
  20. ^ Fagerlund, Riku; Mélen Krister, Kinnunen Leena, Julkunen Ilkka. Arginine/lysine-rich nuclear localization signals mediate interactions between dimeric STATs and importin alpha 5. J. Biol. Chem. (United States). August 2002, 277 (33): 30072–8. ISSN 0021-9258. PMID 12048190. doi:10.1074/jbc.M202943200. 
  21. ^ Deberry, C; Mou S, Linnekin D. Stat1 associates with c-kit and is activated in response to stem cell factor. Biochem. J. (ENGLAND). October 1997, 327 (1): 73–80. ISSN 0264-6021. PMC 1218765  . PMID 9355737. 
  22. ^ Pang, Q; Fagerlie S, Christianson T A, Keeble W, Faulkner G, Diaz J, Rathbun R K, Bagby G C. The Fanconi anemia protein FANCC binds to and facilitates the activation of STAT1 by gamma interferon and hematopoietic growth factors. Mol. Cell. Biol. (United States). July 2000, 20 (13): 4724–35. ISSN 0270-7306. PMC 85895  . PMID 10848598. doi:10.1128/MCB.20.13.4724-4735.2000. 
  23. ^ Reuter, Tanja Y; Medhurst Annette L, Waisfisz Quinten, Zhi Yu, Herterich Sabine, Hoehn Holger, Gross Hans J, Joenje Hans, Hoatlin Maureen E, Mathew Christopher G, Huber Pia A J. Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport. Exp. Cell Res. (United States). October 2003, 289 (2): 211–21. ISSN 0014-4827. PMID 14499622. doi:10.1016/S0014-4827(03)00261-1. 
  24. ^ Pang, Q; Christianson T A, Keeble W, Diaz J, Faulkner G R, Reifsteck C, Olson S, Bagby G C. The Fanconi anemia complementation group C gene product: structural evidence of multifunctionality. Blood (United States). September 2001, 98 (5): 1392–401. ISSN 0006-4971. PMID 11520787. doi:10.1182/blood.V98.5.1392. 
  25. ^ Zhang, J J; Vinkemeier U, Gu W, Chakravarti D, Horvath C M, Darnell J E. Two contact regions between Stat1 and CBP/p300 in interferon gamma signaling. Proc. Natl. Acad. Sci. U.S.A. (United States). Dec 1996, 93 (26): 15092–6. ISSN 0027-8424. PMC 26361  . PMID 8986769. doi:10.1073/pnas.93.26.15092. 
  26. ^ Takeda, Atsunobu; Hamano Shinjiro, Yamanaka Atsushi, Hanada Toshikatsu, Ishibashi Tatsuro, Mak Tak W, Yoshimura Akihiko, Yoshida Hiroki. Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment. J. Immunol. (United States). May 2003, 170 (10): 4886–90. ISSN 0022-1767. PMID 12734330. 
  27. ^ Liao, J; Fu Y, Shuai K. Distinct roles of the NH2- and COOH-terminal domains of the protein inhibitor of activated signal transducer and activator of transcription (STAT) 1 (PIAS1) in cytokine-induced PIAS1-Stat1 interaction. Proc. Natl. Acad. Sci. U.S.A. (United States). May 2000, 97 (10): 5267–72. ISSN 0027-8424. PMC 25817  . PMID 10805787. doi:10.1073/pnas.97.10.5267. 
  28. ^ Ouchi, T; Lee S W, Ouchi M, Aaronson S A, Horvath C M. Collaboration of signal transducer and activator of transcription 1 (STAT1) and BRCA1 in differential regulation of IFN-gamma target genes. Proc. Natl. Acad. Sci. U.S.A. (United States). May 2000, 97 (10): 5208–13. ISSN 0027-8424. PMC 25807  . PMID 10792030. doi:10.1073/pnas.080469697. 
  29. ^ Xie, B; Zhao J, Kitagawa M, Durbin J, Madri J A, Guan J L, Fu X Y. Focal adhesion kinase activates Stat1 in integrin-mediated cell migration and adhesion. J. Biol. Chem. (United States). June 2001, 276 (22): 19512–23. ISSN 0021-9258. PMID 11278462. doi:10.1074/jbc.M009063200. 
  30. ^ 30.0 30.1 Kristof, Arnold S; Marks-Konczalik Joanna, Billings Eric, Moss Joel. Stimulation of signal transducer and activator of transcription-1 (STAT1)-dependent gene transcription by lipopolysaccharide and interferon-gamma is regulated by mammalian target of rapamycin. J. Biol. Chem. (United States). September 2003, 278 (36): 33637–44. ISSN 0021-9258. PMID 12807916. doi:10.1074/jbc.M301053200. 
  31. ^ Li, X; Leung S, Kerr I M, Stark G R. Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling. Mol. Cell. Biol. (United States). April 1997, 17 (4): 2048–56. ISSN 0270-7306. PMC 232052  . PMID 9121453. 
  32. ^ 32.0 32.1 Usacheva, A; Smith R, Minshall R, Baida G, Seng S, Croze E, Colamonici O. The WD motif-containing protein receptor for activated protein kinase C (RACK1) is required for recruitment and activation of signal transducer and activator of transcription 1 through the type I interferon receptor. J. Biol. Chem. (United States). June 2001, 276 (25): 22948–53. ISSN 0021-9258. PMID 11301323. doi:10.1074/jbc.M100087200. 
  33. ^ Wang, Y; Wu T R, Cai S, Welte T, Chin Y E. Stat1 as a component of tumor necrosis factor alpha receptor 1-TRADD signaling complex to inhibit NF-kappaB activation. Mol. Cell. Biol. (United States). July 2000, 20 (13): 4505–12. ISSN 0270-7306. PMC 85828  . PMID 10848577. doi:10.1128/MCB.20.13.4505-4512.2000. 
  34. ^ Zhang, X; Wrzeszczynska M H, Horvath C M, Darnell J E. Interacting regions in Stat3 and c-Jun that participate in cooperative transcriptional activation. Mol. Cell. Biol. (United States). October 1999, 19 (10): 7138–46. ISSN 0270-7306. PMC 84707  . PMID 10490649. 
  35. ^ Vidal, Marcos; Ramana Chilakamarti V, Dusso Adriana S. Stat1-vitamin D receptor interactions antagonize 1,25-dihydroxyvitamin D transcriptional activity and enhance stat1-mediated transcription. Mol. Cell. Biol. (United States). April 2002, 22 (8): 2777–87. ISSN 0270-7306. PMC 133712  . PMID 11909970. doi:10.1128/MCB.22.8.2777-2787.2002. 
  36. ^ Horvath, C M; Stark G R, Kerr I M, Darnell J E. Interactions between STAT and non-STAT proteins in the interferon-stimulated gene factor 3 transcription complex. Mol. Cell. Biol. (United States). Dec 1996, 16 (12): 6957–64. ISSN 0270-7306. PMC 231699  . PMID 8943351. 
  37. ^ Usacheva, Anna; Tian Xinyong, Sandoval Raudel, Salvi Debra, Levy David, Colamonici Oscar R. The WD motif-containing protein RACK-1 functions as a scaffold protein within the type I IFN receptor-signaling complex. J. Immunol. (United States). September 2003, 171 (6): 2989–94. ISSN 0022-1767. PMID 12960323. 

延伸閱讀

外部連結

取自「https://zh.wikipedia.org/w/index.php?title=STAT1&oldid=82737355」