STAT1

位於2號人類染色體的基因

STAT1轉錄因子信號轉導及轉錄激活蛋白(STAT蛋白)家族的一員。

STAT1
已知的結構
PDB直系同源搜索: PDBe RCSB
識別號
別名STAT1;, CANDF7, IMD31A, IMD31B, IMD31C, ISGF-3, STAT91, signal transducer and activator of transcription 1
外部IDOMIM600555 MGI103063 HomoloGene21428 GeneCardsSTAT1
相關疾病
慢性黏膜皮膚念珠菌病、​susceptibility to viral and mycobacterial infections[1]
基因位置(人類
2號染色體
染色體2號染色體[2]
2號染色體
STAT1的基因位置
STAT1的基因位置
基因座2q32.2起始190,908,460 bp[2]
終止191,020,960 bp[2]
RNA表達模式
查閱更多表達數據
直系同源
物種人類小鼠
Entrez
Ensembl
UniProt
mRNA​序列

​NM_007315
​NM_139266

NM_001205313
​NM_001205314
​NM_009283
​NM_001357627

蛋白序列

NP_009330
​NP_644671

無數據

基因位置​(UCSC)Chr 2: 190.91 – 191.02 MbChr 1: 52.16 – 52.2 Mb
PubMed​查找[4][5]
維基數據
檢視/編輯人類檢視/編輯小鼠

STAT1涉及I型II型III型干擾素激活基因的正調控。在干擾素-γ刺激下,STAT1會組成同源二聚體或與STAT3組成異二聚體結合到GAS(Interferon-Gamma-Activated Sequence,干擾素γ激活序列)啟動子上;而在干擾素-α或干擾素-β刺激下,STAT1會與STAT2組成異二聚體結合到ISREInterferon-Stimulated Response Element,干擾素激活反應元件)啟動子上[6]。在這兩種情況下,STAT二聚體與啟動子的結合都會導致ISGInterferon-Stimulated Genes,干擾素激活基因)的表達。

STAT1可由二烯丙基二硫誘導表達[7]

相互作用

STAT1能與下列蛋白質發生相互作用

參考文獻

  1. ^ 與STAT1相關的疾病;在維基數據上查看/編輯參考. 
  2. ^ 2.0 2.1 2.2 GRCh38: Ensembl release 89: ENSG00000115415 - Ensembl, May 2017
  3. ^ 3.0 3.1 3.2 GRCm38: Ensembl release 89: ENSMUSG00000026104 - Ensembl, May 2017
  4. ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  5. ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
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