莫沙必利

化合物

莫沙必利INN:mosapride)是一種胃腸動力藥,選擇性激動5-HT4受體;其主要代謝產物M1還具有5HT3受體的競爭性拮抗作用[1],可加速人體整個胃腸道的排空[2]

莫沙必利
臨床資料
AHFS/Drugs.com國際藥品名稱
給藥途徑口服
ATC碼
  • 未分配
識別資訊
  • (RS)-4-amino-5-chloro-2-ethoxy-N-{[4-(4-fluorobenzyl)morpholin-2-yl]methyl}benzamide
CAS號112885-41-3  checkY
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard英語CompTox Chemicals Dashboard (EPA)
ECHA InfoCard100.127.999 編輯維基數據鏈接
化學資訊
化學式C21H25ClFN3O3
摩爾質量421.893 g/mol
3D模型(JSmol英語JSmol
  • Clc1cc(c(OCC)cc1N)C(=O)NCC3OCCN(Cc2ccc(F)cc2)C3
  • InChI=1S/C21H25ClFN3O3/c1-2-28-20-10-19(24)18(22)9-17(20)21(27)25-11-16-13-26(7-8-29-16)12-14-3-5-15(23)6-4-14/h3-6,9-10,16H,2,7-8,11-13,24H2,1H3,(H,25,27) checkY
  • Key:YPELFRMCRYSPKZ-UHFFFAOYSA-N checkY

莫沙必利用來治療胃炎胃食管反流病功能性消化不良腸易激綜合症[3][4][5],也做為止吐劑,較不會誘發椎體外症候群[6]枸緣酸鹽形式的莫沙必利,由大日本住友製藥在1998年以加斯清為商品名上市銷售。

參見

引用

  1. ^ Tack, J.; Camilleri, M.; Chang, L.; Chey, WD.; Galligan, JJ.; Lacy, BE.; Müller-Lissner, S.; Quigley, EM.; Schuurkes, J. Systematic review: cardiovascular safety profile of 5-HT(4) agonists developed for gastrointestinal disorders.. Aliment Pharmacol Ther. Apr 2012, 35 (7): 745–67. PMID 22356640. doi:10.1111/j.1365-2036.2012.05011.x. 
  2. ^ Odaka T, Suzuki T, Seza A, Yamaguchi T, Saisho H. [Serotonin 5- HT4 receptor agonist (mosapride citrate)]. Nihon Rinsho. Japanese Journal of Clinical Medicine. August 2006, 64 (8): 1491–4. PMID 16898619 (日語). 
  3. ^ Curran MP, Robinson DM. Mosapride in gastrointestinal disorders. Drugs. 2008, 68 (7): 981–91. PMID 18457463. doi:10.2165/00003495-200868070-00007. 
  4. ^ Mizuta Y, Shikuwa S, Isomoto H, Mishima R, Akazawa Y, Masuda J, Omagari K, Takeshima F, Kohno S. Recent insights into digestive motility in functional dyspepsia. Journal of Gastroenterology. 2006 Nov;41(11):1025-40.
  5. ^ Kato S, Morie T, Yoshida N. Synthesis and biological activities of metabolites of mosapride, a new gastroprokinetic agent.Chemical and Pharmaceutical Bulletin (Tokyo). 1995 Apr;43(4):699-702.
  6. ^ 趙容萱. 台中11歲童春節旅遊中邪了?醫師找到原因了. 聯合報. 2023-02-01 [2023-02-01]. (原始內容存檔於2023-03-24).