3-甲基苯甲醚

化合物

3-甲基苯甲醚是一種有機化合物,化學式為C8H10O。它可由3-甲基苯酚碳酸二甲酯十羰基二錳催化反應製得。[4]它和NBS乙腈中於室溫反應,可以得到4-溴-3-甲基苯甲醚;而在四氯化碳中光照回流,得到的主產物為3-甲氧基溴化苄。[5]-氧化汞二氯甲烷[6],或NIS-TFA在乙腈中對其碘化,可以得到4-碘-3-甲基苯甲醚。[1]

3-甲基苯甲醚
別名 間甲基苯甲醚
3-甲氧基甲苯
識別
CAS號 100-84-5  checkY
PubChem 7530
ChemSpider 21106135
SMILES
 
  • O(C1=CC=CC(=C1)C)C
InChI
 
  • InChI=1S/C8H10O/c1-7-4-3-5-8(6-7)9-2/h3-6H,1-2H3
InChIKey OSIGJGFTADMDOB-UHFFFAOYSA-N
性質
化學式 C8H10O
摩爾質量 122.16 g·mol−1
外觀 無色晶體[1]
密度 0.9716 g/mL[2]
熔點 −47 °C(226 K)[3]
−55.92 °C(217.23 K)[2]
沸點 175.5 °C(448.6 K)[3]
176.5 °C(449.6 K)[2]
若非註明,所有數據均出自標準狀態(25 ℃,100 kPa)下。

參考文獻

  1. ^ 1.0 1.1 Two Stereoinduction Events in One C−H Activation Step: A Route towards Terphenyl Ligands with Two Atropisomeric Axes. Angew. Chem. Int. Ed. 2018. doi:10.1002/anie.201801130. Supp Info. pp 19.
  2. ^ 2.0 2.1 2.2 Journal of the American Chemical Society. Volume 69, Issue 10. doi:10.1021/ja01202a060.
  3. ^ 3.0 3.1 "PhysProp" data were obtained from Syracuse Research Corporation of Syracuse, New York (US). Retrieved from SciFinder. [2023-11-16].
  4. ^ Khusnutdinov, R. I., Shchadneva, N. A., & Mayakova, Y. Y. (2015). Methylation of phenol and its derivatives with dimethyl carbonate in the presence of Mn2(CO)10, W(CO)6, and Co2(CO)8. Russian Journal of Organic Chemistry, 51(3), 330–334. doi:10.1134/s1070428015030070
  5. ^ M. Carmen Carreno, Jose L. Garcia Ruano, Gema Sanz, Miguel A. Toledo, and Antonio Urbano. J. Org. Chem. 1995, 60, 16, 5328–5331 doi:10.1021/jo00121a064
  6. ^ Orito, K., Hatakeyama, T., Takeo, M., & Suginome, H. (1995). Iodination of Alkyl Aryl Ethers by Mercury(II) Oxide-Iodine Reagent in Dichloromethane. Synthesis, 1995(10), 1273–1277. doi:10.1055/s-1995-4089