NNC 45-0095

化合物

NNC 45-0095是一種含氮有機化合物,化學式C18H17NO,可作為非甾體選擇性雌激素受體調節物(SERMs),由諾和諾德開發,用於治療骨質疏鬆症,從未上市銷售。[1][2][3][4][5]

NNC 45-0095
臨床資料
其他名稱NNC-450095
藥物類別英語Drug class選擇性雌激素受體調節物
識別資訊
  • 4-(1-ethylpyrrolo[2,1,5-cd]indolizin-2-yl)phenol
CAS號217318-90-6
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard英語CompTox Chemicals Dashboard (EPA)
化學資訊
化學式C18H15NO
摩爾質量261.32 g·mol−1
3D模型(JSmol英語JSmol
  • CCC1=C(C2=CC=C3N2C1=CC=C3)C4=CC=C(C=C4)O
  • InChI=1S/C18H15NO/c1-2-15-16-5-3-4-13-8-11-17(19(13)16)18(15)12-6-9-14(20)10-7-12/h3-11,20H,2H2,1H3
  • Key:GBHFDPQPLXKNIU-UHFFFAOYSA-N

參考文獻

  1. ^ Jørgensen AS, Jacobsen P, Christiansen LB, Bury PS, Kanstrup A, Thorpe SM, et al. Synthesis and pharmacology of a novel pyrrolo[2,1,5-cd] indolizine (NNC 45-0095), a high affinity non-steroidal agonist for the estrogen receptor. Bioorganic & Medicinal Chemistry Letters. February 2000, 10 (4): 399–402. PMID 10714509. doi:10.1016/S0960-894X(00)00015-9. 
  2. ^ Sharma V, Kumar V. Indolizine: a biologically active moiety. Medicinal Chemistry Research. 2014, 23 (8): 3593–3606. ISSN 1054-2523. S2CID 2643469. doi:10.1007/s00044-014-0940-1. 
  3. ^ Wallace OB, Richardson TI, Dodge JA. Estrogen receptor modulators: relationships of ligand structure, receptor affinity and functional activity. Current Topics in Medicinal Chemistry. 2003, 3 (14): 1663–1682. PMID 14683521. doi:10.2174/1568026033451727. 
  4. ^ Meegan MJ, Lloyd DG. Understanding the Molecular Mechanism of Action of Estrogen Receptor Modulators. Frontiers in Medicinal Chemistry-Online. Atta-ur-Rahman, Reitz AB (編). Frontiers in Medicinal Chemistry 2. Bentham Science Publishers. January 2005: 183–231 (206). ISBN 978-1-60805-205-9.  |issue=被忽略 (幫助)
  5. ^ NNC 450095. AdisInsight. Springer Nature Switzerland AG. [2024-01-18]. (原始內容存檔於2024-01-18).