碘氰吲哚洛爾

碘氰吲哚洛爾(INN:Iodocyanopindolol)是一種與吲哚洛爾相關的藥物,既可作為β1腎上腺素能受體拮抗劑,又可作為5-HT1A受體拮抗劑。其125I放射性標記衍生物已廣泛用於繪製體內β腎上腺素能受體的分佈圖。[1]

碘氰吲哚洛爾
Skeletal formula of iodocyanopindolol
Space-filling model of the iodocyanopindolol molecule
臨床資料
ATC碼
  • 未分配
識別資訊
  • (RS)-4-[3-[(1,1-Dimethylethyl)amino]-2-hydroxypropoxy]-3-iodo-1H-indole-2-carbonitrile
CAS號85124-14-7  checkY
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
ChEBI
ChEMBL
CompTox Dashboard英語CompTox Chemicals Dashboard (EPA)
化學資訊
化學式C16H20IN3O2
摩爾質量413.26 g·mol−1
3D模型(JSmol英語JSmol
手性外消旋混合物
  • IC1=C(C#N)NC2=CC=CC(OCC(CNC(C)(C)C)O)=C21
  • InChI=1S/C16H20IN3O2/c1-16(2,3)19-8-10(21)9-22-13-6-4-5-11-14(13)15(17)12(7-18)20-11/h4-6,10,19-21H,8-9H2,1-3H3
  • Key:JBLUMBNIBNHRSO-UHFFFAOYSA-N

參考資料

  1. ^ Brodde OE, Karad K, Zerkowski HR, Rohm N, Reidemeister JC. Coexistence of beta 1- and beta 2-adrenoceptors in human right atrium. Direct identification by (+/-)-[125I]iodocyanopindolol binding. Circulation Research. 1983, 53 (6): 752–758. PMID 6139182. doi:10.1161/01.res.53.6.752 . 


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