那吶妥單抗
化合物
那吶妥單抗(INN:Narnatumab;開發代號:IMC-RON8、LY3012219)[1]是一種針對RON受體的人單株抗體,設計用於治療直腸癌和由淋巴管生成引起的實體瘤。[2]該藥物目前已經進行了I期臨床試驗。[1][2][3]
單株抗體 | |
---|---|
種類 | 完整抗體 |
目標 | RON |
臨床資料 | |
ATC碼 |
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識別資訊 | |
CAS號 | 1188275-92-4 ![]() |
ChemSpider |
|
UNII | |
KEGG | |
化學資訊 | |
化學式 | C6454H10026N1754O2020S44 |
摩爾質量 | 145,922.10 g·mol−1 |
那吶妥單抗由ImClone Systems開發。[4]
參考資料
- ^ 1.0 1.1 LoRusso, Patricia M.; Gounder, Mrinal; Jalal, Shadia I.; André, Valérie; Kambhampati, Siva Rama Prasad; Loizos, Nick; Hall, Jennifer; Holzer, Timothy R.; Nasir, Aejaz; Cosaert, Jan; Kauh, John. Phase 1 study of narnatumab, an anti-RON receptor monoclonal antibody, in patients with advanced solid tumors. Investigational New Drugs. 2017-08, 35 (4) [2024-01-24]. ISSN 1573-0646. PMC 5502198 . PMID 28161886. doi:10.1007/s10637-016-0413-0. (原始內容存檔於2024-01-24).
- ^ 2.0 2.1 Saif, Muhammad Wasif; Knost, James A.; Chiorean, E. Gabriela; Kambhampati, Siva Rama Prasad; Yu, Danni; Pytowski, Bronislaw; Qin, Amy; Kauh, John S.; O'Neil, Bert H. Phase 1 study of the anti-vascular endothelial growth factor receptor 3 monoclonal antibody LY3022856/IMC-3C5 in patients with advanced and refractory solid tumors and advanced colorectal cancer. Cancer Chemotherapy and Pharmacology. 2016-10, 78 (4) [2024-01-24]. ISSN 1432-0843. PMID 27566701. doi:10.1007/s00280-016-3134-3. (原始內容存檔於2024-03-22).
- ^ Yu Koh, Xin; Koh, Xin Yu; Xiao Hui Koh; Spiegelberg, Diana; Jha, Preeti; Nestor, Marika; Hwang, Le-ann; Tan, Ban Xiong; Lane, David Philip. Conformation specific antagonistic high affinity antibodies to the RON receptor kinase for imaging and therapy. Scientific Reports. 2022-12-29, 12 (1) [2024-01-24]. ISSN 2045-2322. doi:10.1038/s41598-022-26404-7. (原始內容存檔於2024-01-24) (英語).
- ^ Narnatumumab. AdisInsight. [31 January 2017]. (原始內容存檔於2024-01-24).