EGLU

EGLU
識別資訊
	IUPAC命名法 (2S)-2-Amino-2-ethylpentanedioic acid; ;
CAS號	170984-72-2 [yes]
PubChem CID	5311079;
IUPHAR/BPS	1400;
ChemSpider	4470613 ;
CompTox Dashboard（英語：CompTox Chemicals Dashboard） (EPA)	DTXSID50415504 ;
化學資訊
化學式	C7H13NO4
摩爾質量	175.18 g·mol−1
3D模型（JSmol（英語：JSmol））	交互式圖像;
	SMILES O=C(O)CC[C@](N)(C(=O)O)CC;
	InChI InChI=1S/C7H13NO4/c1-2-7(8,6(11)12)4-3-5(9)10/h2-4,8H2,1H3,(H,9,10)(H,11,12)/t7-/m0/s1 ; Key:QFYBYZLHPIALCZ-ZETCQYMHSA-N ;

EGLU（全稱(2S)-α-乙基穀氨酸，英語：(2S)-α-ethylglutamic acid）是一種含氮有機化合物，分子式C₇H₁₃NO₄，是首個發現的II型代謝型穀氨酸受體（mGluR_2/3）的選擇性拮抗劑。^[1]^[2]^[3]^[4]^[5]^[6]^[7]

參考文獻

^ Jane DE, Thomas NK, Tse HW, Watkins JC. Potent antagonists at the L-AP4- and (1S,3S)-ACPD-sensitive presynaptic metabotropic glutamate receptors in the neonatal rat spinal cord. Neuropharmacology. 1996, 35 (8): 1029–35. PMID 9121605. S2CID 6238847. doi:10.1016/S0028-3908(96)00048-2.
^ Huang L, Rowan MJ, Anwyl R. Induction of long-lasting depression by (+)-alpha-methyl-4-carboxyphenylglycine and other group II mGlu receptor ligands in the dentate gyrus of the hippocampus in vitro. European Journal of Pharmacology. February 1999, 366 (2–3): 151–8. PMID 10082195. doi:10.1016/S0014-2999(98)00918-2.
^ Palazzo E, Marabese I, de Novellis V, Oliva P, Rossi F, Berrino L, et al. Metabotropic and NMDA glutamate receptors participate in the cannabinoid-induced antinociception. Neuropharmacology. March 2001, 40 (3): 319–26. PMID 11166324. S2CID 41189905. doi:10.1016/S0028-3908(00)00160-X.
^ Iserhot C, Gebhardt C, Schmitz D, Heinemann U. Glutamate transporters and metabotropic receptors regulate excitatory neurotransmission in the medial entorhinal cortex of the rat. Brain Research. November 2004, 1027 (1–2): 151–60. PMID 15494166. S2CID 33373525. doi:10.1016/j.brainres.2004.08.052.
^ Cahusac PM, Wan H. Group II metabotropic glutamate receptors reduce excitatory but not inhibitory neurotransmission in rat barrel cortex in vivo. Neuroscience. April 2007, 146 (1): 202–12. PMID 17346894. S2CID 37975672. doi:10.1016/j.neuroscience.2007.01.049.
^ Kim WY, Vezina P, Kim JH. Blockade of group II, but not group I, mGluRs in the rat nucleus accumbens inhibits the expression of conditioned hyperactivity in an amphetamine-associated environment. Behavioural Brain Research. August 2008, 191 (1): 62–6. PMID 18433894. S2CID 24250755. doi:10.1016/j.bbr.2008.03.010.
^ Altinbilek B, Manahan-Vaughan D. A specific role for group II metabotropic glutamate receptors in hippocampal long-term depression and spatial memory. Neuroscience. January 2009, 158 (1): 149–58. PMID 18722513. S2CID 40251815. doi:10.1016/j.neuroscience.2008.07.045.

[1] Jane DE, Thomas NK, Tse HW, Watkins JC. Potent antagonists at the L-AP4- and (1S,3S)-ACPD-sensitive presynaptic metabotropic glutamate receptors in the neonatal rat spinal cord. Neuropharmacology. 1996, 35 (8): 1029–35. PMID 9121605. S2CID 6238847. doi:10.1016/S0028-3908(96)00048-2.

[2] Huang L, Rowan MJ, Anwyl R. Induction of long-lasting depression by (+)-alpha-methyl-4-carboxyphenylglycine and other group II mGlu receptor ligands in the dentate gyrus of the hippocampus in vitro. European Journal of Pharmacology. February 1999, 366 (2–3): 151–8. PMID 10082195. doi:10.1016/S0014-2999(98)00918-2.

[3] Palazzo E, Marabese I, de Novellis V, Oliva P, Rossi F, Berrino L, et al. Metabotropic and NMDA glutamate receptors participate in the cannabinoid-induced antinociception. Neuropharmacology. March 2001, 40 (3): 319–26. PMID 11166324. S2CID 41189905. doi:10.1016/S0028-3908(00)00160-X.

[4] Iserhot C, Gebhardt C, Schmitz D, Heinemann U. Glutamate transporters and metabotropic receptors regulate excitatory neurotransmission in the medial entorhinal cortex of the rat. Brain Research. November 2004, 1027 (1–2): 151–60. PMID 15494166. S2CID 33373525. doi:10.1016/j.brainres.2004.08.052.

[5] Cahusac PM, Wan H. Group II metabotropic glutamate receptors reduce excitatory but not inhibitory neurotransmission in rat barrel cortex in vivo. Neuroscience. April 2007, 146 (1): 202–12. PMID 17346894. S2CID 37975672. doi:10.1016/j.neuroscience.2007.01.049.

[6] Kim WY, Vezina P, Kim JH. Blockade of group II, but not group I, mGluRs in the rat nucleus accumbens inhibits the expression of conditioned hyperactivity in an amphetamine-associated environment. Behavioural Brain Research. August 2008, 191 (1): 62–6. PMID 18433894. S2CID 24250755. doi:10.1016/j.bbr.2008.03.010.

[7] Altinbilek B, Manahan-Vaughan D. A specific role for group II metabotropic glutamate receptors in hippocampal long-term depression and spatial memory. Neuroscience. January 2009, 158 (1): 149–58. PMID 18722513. S2CID 40251815. doi:10.1016/j.neuroscience.2008.07.045.

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識別資訊

IUPAC命名法 (2S)-2-Amino-2-ethylpentanedioic acid
CAS號	170984-72-2 ^Y[yes]
PubChem CID	5311079
IUPHAR/BPS	1400
ChemSpider	4470613^N
CompTox Dashboard（英語：CompTox Chemicals Dashboard） (EPA)	DTXSID50415504
化學資訊
化學式	C₇H₁₃NO₄
摩爾質量	175.18 g·mol⁻¹
3D模型（JSmol（英語：JSmol））	交互式圖像
SMILES O=C(O)CC[C@](N)(C(=O)O)CC
InChI InChI=1S/C7H13NO4/c1-2-7(8,6(11)12)4-3-5(9)10/h2-4,8H2,1H3,(H,9,10)(H,11,12)/t7-/m0/s1^N Key:QFYBYZLHPIALCZ-ZETCQYMHSA-N^N