转录泡泡(Transcription bubble)是在DNA转录过程中,当DNA双链的局部解旋时所形成的分子结构。转录泡泡的大小范围为12-14个碱基对。当RNA聚合酶启动子结合并导致两条DNA链分离时,就会形成转录泡泡。[1]它显示了一个未配对的DNA区域,在双螺旋的每条链上都暴露出一小段核苷酸[1][2]

A molecular structure composed of unwound and unpaired DNA, where a short stretch of nucleotides are exposed on each strand of the double helix, allowing RNA polymerase binding, and nascent RNA synthesis within this region.

RNA聚合酶

参见

参考资料

  1. ^ 1.0 1.1 Alberts, Bruce; Johnson, Alexander; Lewis, Julian; Morgan, David; Raff, Martin; Roberts, Keith; Walter, Peter. Wilson, John; Hunt, Tim , 编. Molecular Biology of the Cell 6. Garland Science. 2015: 306–307. ISBN 9781315735368. doi:10.1201/9781315735368 (英语). 
  2. ^ Clark, David P.; Pazdernik, Nanette J., Clark, David P.; Pazdernik, Nanette J. , 编, Chapter 2 - DNA, RNA, and Protein, Biotechnology (Second Edition) (Academic Cell), 2016-01-01: 33–61 [2019-09-30], ISBN 9780123850157, doi:10.1016/b978-0-12-385015-7.00002-8, (原始内容存档于2023-02-13)