8,9-脱氢雌酮

化合物

8,9-脱氢雌酮(英语:8,9-Dehydroestrone,Δ8-estrone)也称为异马烯雌酮(英语:isoequilin)是一种存在于中的天然雌激素,半系统名:雌甾-1,3,5(10),8-四烯-3-醇-17-酮,estra-1,3,5(10),8-tetraen-3-ol-17-one[1]。8,9-脱氢雌酮的3-硫酸酯是结合型雌激素(普立马)的成分之一,约占3.5%[2]。8,9-脱氢雌酮在体内可转化成8,9-脱氢雌二醇,过程类似于雌酮转化成雌二醇[3][4]

8,9-脱氢雌酮
临床资料
其他名称Δ8-Estrone; Estra-1,3,5(10),8-tetraen-3-ol-17-one
给药途径By mouth
药物类别英语Drug classEstrogen
识别信息
  • (13S,14S)-3-Hydroxy-13-methyl-7,11,12,14,15,16-hexahydro-6H-cyclopenta[a]phenanthren-17-one
CAS号474-87-3
PubChem CID
ChemSpider
UNII
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
化学信息
化学式C18H20O2
摩尔质量268.36 g·mol−1
3D模型(JSmol英语JSmol
  • C[C@]12CCC3=C([C@@H]1CCC2=O)CCC4=C3C=CC(=C4)O
  • InChI=1S/C18H20O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,16,19H,2,4,6-9H2,1H3/t16-,18-/m0/s1
  • Key:OUGSRCWSHMWPQE-WMZOPIPTSA-N

参考文献

  1. ^ Baracat E, Haidar M, Lopez FJ, Pickar J, Dey M, Negro-Vilar A. Estrogen activity and novel tissue selectivity of delta8,9-dehydroestrone sulfate in postmenopausal women. J. Clin. Endocrinol. Metab. June 1999, 84 (6): 2020–7. PMID 10372704. doi:10.1210/jcem.84.6.5800 . 
  2. ^ Marc A. Fritz; Leon Speroff. Clinical Gynecologic Endocrinology and Infertility. Lippincott Williams & Wilkins. 28 March 2012: 751– [2022-02-06]. ISBN 978-1-4511-4847-3. (原始内容存档于2021-05-03). 
  3. ^ Bhavnani BR. Pharmacokinetics and pharmacodynamics of conjugated equine estrogens: chemistry and metabolism. Proc. Soc. Exp. Biol. Med. January 1998, 217 (1): 6–16. PMID 9421201. S2CID 45177839. doi:10.3181/00379727-217-44199. 
  4. ^ Bhavnani BR, Cecutti A, Gerulath A. Pharmacokinetics and pharmacodynamics of a novel estrogen delta8-estrone in postmenopausal women and men. J. Steroid Biochem. Mol. Biol. October 1998, 67 (2): 119–31. PMID 9877212. S2CID 54352249. doi:10.1016/s0960-0760(98)00082-x.