天冬氨酸酰酶

Aspartoacylase
	Structure of aspartoacylase dimer. Generated from 2I3C.
命名
系统命名
缩写
识别码
EC编号	3.5.1.15
数据库
IntEnz	IntEnz浏览
BRENDA（英语：BRENDA）	BRENDA入口
ExPASy（英语：ExPASy）	NiceZyme浏览
KEGG	KEGG入口
MetaCyc（英语：MetaCyc）	代谢路径
PRIAM（英语：PRIAM_enzyme-specific_profiles）	概述
PDB	RCSB PDB PDBj PDBe PDBsum
搜索
PMC	相关文献
PubMed	相关文献

天冬氨酸酰酶
已知的结构
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	4MRI、2I3C、2O4H、2Q51、2O53、4NFR、4MXU、4TNU
识别号
别名	ASPA；, ACY2, ASP, aspartoacylase
外部ID	OMIM：608034 MGI：87914 HomoloGene：33 GeneCards：ASPA
相关疾病
	卡纳万病
基因位置（人类）
染色体	17号染色体
终止	3,503,405 bp
基因位置（小鼠）
染色体	小鼠11号染色体
终止	73,220,422 bp
基因本体
分子功能	• 血浆蛋白结合; • 水解酶活性; • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; • 金属离子结合; • hydrolase activity, acting on ester bonds; • aspartoacylase activity; • aminoacylase activity; • 相同蛋白质结合;
细胞组分	• 细胞核; • 细胞质; • 细胞质基质;
生物学过程	• 代谢; • cellular amino acid biosynthetic process; • aspartate catabolic process; • central nervous system myelination; • positive regulation of oligodendrocyte differentiation;
	Sources:Amigo / QuickGO
直系同源
	443
	11484
	ENSG00000108381
	ENSMUSG00000020774
	P45381
	Q8R3P0
	NM_000049; NM_001128085
	NM_023113
	NP_000040; NP_001121557
	NP_075602
	维基数据
查看/编辑人类	查看/编辑小鼠

ACY2（氨基酰化酶2，英语：aminoacylase II，缩写ACY-2，也称为天冬氨酸酰酶，英语：Aspartoacylase，缩写ASPA）是一个人类基因 ASPA 编码的蛋白质，是一种催化N-乙酰天冬氨酸水解为天冬氨酸和乙酸的水解酶，EC编号3.5.1.15，位于人类第17号染色体上17p13.2区域。^[7]^[8]

参考文献

^ 與天冬氨酸酰酶相關的疾病；在維基數據上查看/編輯參考.
^ ^2.0 ^2.1 ^2.2 GRCh38: Ensembl release 89: ENSG00000108381 - Ensembl, May 2017
^ ^3.0 ^3.1 ^3.2 GRCm38: Ensembl release 89: ENSMUSG00000020774 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Bitto E, Bingman CA, Wesenberg GE, McCoy JG, Phillips GN. Structure of aspartoacylase, the brain enzyme impaired in Canavan disease. Proceedings of the National Academy of Sciences of the United States of America. January 2007, 104 (2): 456–61. PMC 1766406  . PMID 17194761. doi:10.1073/pnas.0607817104  .
^ Birnbaum SM. Aminoacylase. Amino acid aminoacylases I and II from hog kidney. Methods in Enzymology 2. 1955: 115–119. ISBN 9780121818029. doi:10.1016/S0076-6879(55)02176-9. |journal=被忽略 (帮助)
^ Birnbaum SM, Levintow L, Kingsley RB, Greenstein JP. Specificity of amino acid acylases. The Journal of Biological Chemistry. January 1952, 194 (1): 455–70. PMID 14927637. doi:10.1016/S0021-9258(18)55898-1  .

外部链接

医学主题词表（MeSH）：aspartoacylase
PDB中UniProt可用的所有结构信息之概述：P45381 (Aspartoacylase) 在PDBe-KB（英语：PDBe-KB）。

[1] 與天冬氨酸酰酶相關的疾病；在維基數據上查看/編輯參考.

[refGRCh38Ensembl-2] 2.0 ^2.1 ^2.2 GRCh38: Ensembl release 89: ENSG00000108381 - Ensembl, May 2017

[refGRCm38Ensembl-3] 3.0 ^3.1 ^3.2 GRCm38: Ensembl release 89: ENSMUSG00000020774 - Ensembl, May 2017

[4] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[Bitto_2007-6] Bitto E, Bingman CA, Wesenberg GE, McCoy JG, Phillips GN. Structure of aspartoacylase, the brain enzyme impaired in Canavan disease. Proceedings of the National Academy of Sciences of the United States of America. January 2007, 104 (2): 456–61. PMC 1766406  . PMID 17194761. doi:10.1073/pnas.0607817104  .

[7] Birnbaum SM. Aminoacylase. Amino acid aminoacylases I and II from hog kidney. Methods in Enzymology 2. 1955: 115–119. ISBN 9780121818029. doi:10.1016/S0076-6879(55)02176-9. |journal=被忽略 (帮助)

[8] Birnbaum SM, Levintow L, Kingsley RB, Greenstein JP. Specificity of amino acid acylases. The Journal of Biological Chemistry. January 1952, 194 (1): 455–70. PMID 14927637. doi:10.1016/S0021-9258(18)55898-1  .

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