托非索泮

化合物

托非索泮(英语:Tofisopam、Emandaxin、Grandaxin、Sériel)是一种含氮有机化合物[3],化学式C22H26N2O4[4],属于苯二氮䓬类药物,在欧洲作为抗焦虑药销售。

托非索泮
临床资料
其他名称6-(3,4-Dimethoxyphenyl)-2-ethyl-9,10-dimethoxy-3-methyl-4,5-diazabicyclo[5.4.0]undeca-3,5,7,9,11-pentaene
AHFS/Drugs.com国际药品名称
给药途径By mouth (tablets)
ATC码
法律规范状态
法律规范
  • 处方药(-only)
药物动力学数据
药物代谢Hepatic
生物半衰期3 hours[1][2]
排泄途径Renal
识别信息
  • 1-(3,4-dimethoxyphenyl)-5-ethyl-7,8-dimethoxy-4-methyl-5H-2,3-benzodiazepine
CAS号22345-47-7  checkY
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
ECHA InfoCard100.040.823 编辑维基数据链接
化学信息
化学式C22H26N2O4
摩尔质量382.46 g·mol−1
3D模型(JSmol英语JSmol
  • O(c3ccc(C\2=N\N=C(/C(c1c/2cc(OC)c(OC)c1)CC)C)cc3OC)C
  • InChI=1S/C22H26N2O4/c1-7-15-13(2)23-24-22(14-8-9-18(25-3)19(10-14)26-4)17-12-21(28-6)20(27-5)11-16(15)17/h8-12,15H,7H2,1-6H3 checkY
  • Key:RUJBDQSFYCKFAA-UHFFFAOYSA-N checkY

参考文献

  1. ^ Klebovich I, Abermann M. [Pharmacokinetics and metabolism of tofizopam (Grandaxin)]. Acta Pharm Hung. March 1993, 63 (2): 83–90. PMID 8100113 (Hungarian). 
  2. ^ Rundfeldt C, Socała K, Wlaź P. The atypical anxiolytic drug, tofisopam, selectively blocks phosphodiesterase isoenzymes and is active in the mouse model of negative symptoms of psychosis. J Neural Transm (Vienna). November 2010, 117 (11): 1319–25. PMC 2993883 . PMID 20967473. doi:10.1007/s00702-010-0507-3. 
  3. ^ DE Patent 2122070
  4. ^ Index Nominum 2000: International Drug Directory. Taylor & Francis. January 2000: 1041. ISBN 978-3-88763-075-1. 

外部链接