美西林

青霉素

美西林INN:Mecillinam;USAN:Amdinocillin)是一种广谱半合成青霉素[2],对革兰氏阴性菌作用强,也可用来治疗伤寒副伤寒[3][4]。其口服利用率很差,匹美西林则是针对此缺陷开发出来的。[5]

美西林
临床资料
商品名英语Drug nomenclatureCoactin, Leo, Selexid, Selexidin
AHFS/Drugs.com国际药品名称
怀孕分级
给药途径静脉注射肌肉注射
ATC码
法律规范状态
法律规范
药物动力学数据
生物利用度可忽略
血浆蛋白结合率5-10%
药物代谢肝脏
生物半衰期1-3小时
排泄途径肾、胆
识别信息
  • (2S,5R,6R)-6-[(E/Z)-(Azepan-1-ylmethylene)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
CAS号32887-01-7  checkY
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
ECHA InfoCard100.046.601 编辑维基数据链接
化学信息
化学式C15H23N3O3S
摩尔质量325.426 g/mol
3D模型(JSmol英语JSmol
  • CC1([C@@H](N2[C@H](S1)[C@@H](C2=O)N=CN3CCCCCC3)C(=O)O)C

这种药物是荷兰制药公司“Leo Pharmaceutical Products”(今利奥制药)研发出来的,最初代号为FL 1060,1972年面世。[6][7]

参考文献

  1. ^ Nicolle LE. Pivmecillinam in the treatment of urinary tract infections. J Antimicrob Chemother. August 2000, 46 (Suppl A): 35–39. PMID 10969050. doi:10.1093/jac/46.suppl_1.35. 
  2. ^ Neu HC. Amdinocillin: a novel penicillin. Antibacterial activity, pharmacology and clinical use. Pharmacotherapy. 1985, 5 (1): 1–10. PMID 3885172. doi:10.1002/j.1875-9114.1985.tb04448.x. 
  3. ^ Clarke PD, Geddes AM, McGhie D, Wall JC. Mecillinam: a new antibiotic for enteric fever. Br Med J. July 1976, 2 (6026): 14–5. PMC 1687648 . PMID 820402. doi:10.1136/bmj.2.6026.14. 
  4. ^ Geddes AM, Clarke PD. The treatment of enteric fever with mecillinam. J Antimicrob Chemother. July 1977,. 3 Suppl B: 101–2. PMID 408321. doi:10.1093/jac/3.suppl_b.101. 
  5. ^ Pham P, Bartlett JG. Amdinocillin (Mecillinam). Point-of-Care Information Technology ABX Guide. Johns Hopkins University. August 28, 2008 [2019-03-08]. (原始内容存档于2009-02-04).  Retrieved on August 31, 2008. Freely available with registration.
  6. ^ Lund F, Tybring L. 6β-amidinopenicillanic acids—a new group of antibiotics. Nature New Biology. April 1972, 236 (66): 135–7. PMID 4402006. doi:10.1038/236135c0. 
  7. ^ Tybring L, Melchior NH. Mecillinam (FL 1060), a 6β-Amidinopenicillanic Acid Derivative: Bactericidal Action and Synergy In Vitro. Antimicrob Agents Chemother. September 1975, 8 (3): 271–6 [2019-03-08]. PMC 429305 . PMID 170856. doi:10.1128/aac.8.3.271. (原始内容存档于2019-12-14).