蛋白酪氨酸磷酸酶C型受体

蛋白酪氨酸磷酸酶C型受体
已知的结构
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	1YGU、1YGR、5FMV、5FN6、5FN7
识别号
别名	PTPRC；, B220, CD45, CD45R, GP180, L-CA, LCA, LY5, T200, protein tyrosine phosphatase, receptor type C, protein tyrosine phosphatase receptor type C
外部ID	OMIM：151460 MGI：97810 HomoloGene：2126 GeneCards：PTPRC
相关疾病
	溃疡性结肠炎
基因位置（人类）
染色体	1号染色体
终止	198,757,476 bp
基因位置（小鼠）
染色体	小鼠1号染色体
终止	138,103,446 bp
RNA表达模式
	; ; ; ;
	查阅更多表达数据
基因本体
分子功能	• phosphoprotein phosphatase activity; • phosphatase activity; • 血浆蛋白结合; • transmembrane receptor protein tyrosine phosphatase activity; • protein kinase binding; • 水解酶活性; • protein tyrosine phosphatase activity;
细胞组分	• integral component of membrane; • 膜; • 粘着斑; • 细胞膜; • integral component of plasma membrane; • cell surface; • 脂筏模型; • 外排体; • external side of plasma membrane; • secretory granule membrane;
生物学过程	• B cell receptor signaling pathway; • cell cycle phase transition; • release of sequestered calcium ion into cytosol; • negative regulation of protein kinase activity; • bone marrow development; • stem cell development; • 蛋白质去磷酸化; • negative regulation of cytokine-mediated signaling pathway; • positive regulation of hematopoietic stem cell migration; • regulation of cell cycle; • negative regulation of cell adhesion involved in substrate-bound cell migration; • negative regulation of T cell mediated cytotoxicity; • cell surface receptor signaling pathway; • B cell proliferation; • T cell differentiation; • positive regulation of B cell proliferation; • defense response to virus; • positive regulation of T cell proliferation; • hematopoietic progenitor cell differentiation; • positive regulation of antigen receptor-mediated signaling pathway; • T cell receptor signaling pathway; • positive regulation of stem cell proliferation; • 去磷酸化; • positive regulation of protein kinase activity; • peptidyl-tyrosine dephosphorylation; • neutrophil degranulation;
	Sources:Amigo / QuickGO
直系同源
	5788
	19264
	ENSG00000081237; ENSG00000262418
	ENSMUSG00000026395
	P08575
	P06800
	NM_001267798; NM_002838; NM_080921; NM_080922
	NM_001111316; NM_001268286; NM_011210
	NP_001254727; NP_002829; NP_563578; NP_563578.2; NP_002829.3
	NP_001104786; NP_001255215; NP_035340
	维基数据
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蛋白酪氨酸磷酸酶C型受体（英语：Protein tyrosine phosphatase, receptor type, C，缩写：PTPRC）是一个由PTPRC人类基因编码的酶^[6] 蛋白酪氨酸磷酸酶C型受体又叫做45号分化簇抗原，以前曾叫白细胞常见抗原（英语：leukocyte common antigen，缩写：LCA）。^[7]