C5a受体(英语:C5a receptor或称补体成分5a受体1,complement component 5a receptor 1C5AR1CD88Cluster of Differentiation 88)是一种与补体C5a英语Complement component 5a相结合的G蛋白偶联受体[5]

C5a受体
识别号
别名C5AR1;, C5A, C5AR, C5R1, CD88, complement component 5a receptor 1, C5a receptor, complement C5a receptor 1
外部IDOMIM113995 MGI88232 HomoloGene20413 GeneCardsC5AR1
基因位置(人类
19号染色体
染色体19号染色体[1]
19号染色体
C5a受体的基因位置
C5a受体的基因位置
基因座19q13.32起始47,290,023 bp[1]
终止47,322,066 bp[1]
RNA表达模式
查阅更多表达数据
直系同源
物种人类小鼠
Entrez
Ensembl
UniProt
mRNA​序列

NM_001736

NM_001173550
​NM_007577

蛋白序列

NP_001727

NP_001167021
​NP_031603

基因位置​(UCSC)Chr 19: 47.29 – 47.32 MbChr 7: 15.98 – 15.99 Mb
PubMed​查找[3][4]
维基数据
查看/编辑人类查看/编辑小鼠
C5a受体结构及其与配体结合信号转导相关的氨基酸残基

细胞

C5a受体表达于以下细胞:[6]

另见

参考文献

  1. ^ 1.0 1.1 1.2 GRCh38: Ensembl release 89: ENSG00000197405 - Ensembl, May 2017
  2. ^ 2.0 2.1 2.2 GRCm38: Ensembl release 89: ENSMUSG00000049130 - Ensembl, May 2017
  3. ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  4. ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  5. ^ Gerard C, Gerard NP. C5A anaphylatoxin and its seven transmembrane-segment receptor. Annu. Rev. Immunol. 1994, 12: 775–808. PMID 8011297. doi:10.1146/annurev.iy.12.040194.004015. 
  6. ^ Klos A, Wende E, Wareham KJ, Monk PN. International Union of Pharmacology. LXXXVII. Complement peptide C5a, C4a, and C3a receptors. Pharmacol. Rev. 2013, 65 (1): 500–43. PMID 23383423. doi:10.1124/pr.111.005223. 

延伸阅读

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  • Yamamoto T. Roles of the ribosomal protein S19 dimer and the C5a receptor in pathophysiological functions of phagocytic leukocytes.. Pathol. Int. 2007, 57 (1): 1–11. PMID 17199736. doi:10.1111/j.1440-1827.2007.02049.x. 
  • Bao L, Gerard NP, Eddy RL; et al. Mapping of genes for the human C5a receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1, FPRH2) to chromosome 19.. Genomics. 1992, 13 (2): 437–40. PMID 1612600. doi:10.1016/0888-7543(92)90265-T. 
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  • Wahl SM, Allen JB, Gartner S; et al. HIV-1 and its envelope glycoprotein down-regulate chemotactic ligand receptors and chemotactic function of peripheral blood monocytes.. J. Immunol. 1989, 142 (10): 3553–9. PMID 2541200. 
  • Foreman KE, Vaporciyan AA, Bonish BK; et al. C5a-induced expression of P-selectin in endothelial cells.. J. Clin. Invest. 1994, 94 (3): 1147–55. PMC 295185 . PMID 7521884. doi:10.1172/JCI117430. 
  • Giannini E, Brouchon L, Boulay F. Identification of the major phosphorylation sites in human C5a anaphylatoxin receptor in vivo.. J. Biol. Chem. 1995, 270 (32): 19166–72. PMID 7642584. doi:10.1074/jbc.270.32.19166. 
  • Buhl AM, Osawa S, Johnson GL. Mitogen-activated protein kinase activation requires two signal inputs from the human anaphylatoxin C5a receptor.. J. Biol. Chem. 1995, 270 (34): 19828–32. PMID 7649993. doi:10.1074/jbc.270.34.19828. 
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  • Werfel T, Zwirner J, Oppermann M; et al. CD88 antibodies specifically bind to C5aR on dermal CD117+ and CD14+ cells and react with a desmosomal antigen in human skin.. J. Immunol. 1996, 157 (4): 1729–35. PMID 8759762. 
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  • Chen Z, Zhang X, Gonnella NC; et al. Residues 21-30 within the extracellular N-terminal region of the C5a receptor represent a binding domain for the C5a anaphylatoxin.. J. Biol. Chem. 1998, 273 (17): 10411–9. PMID 9553099. doi:10.1074/jbc.273.17.10411. 
  • Floreani AA, Heires AJ, Welniak LA; et al. Expression of receptors for C5a anaphylatoxin (CD88) on human bronchial epithelial cells: enhancement of C5a-mediated release of IL-8 upon exposure to cigarette smoke.. J. Immunol. 1998, 160 (10): 5073–81. PMID 9590258. 
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外部链接