HLA-B

HLA-B是人类白细胞抗原（HLA）的一个基因座，位于6号染色体上。

HLA-B
已知的结构 PDB 人类UniProt搜索: PDBe RCSB PDBID列表 3VCL、​4U1H、​4U1K、​5EO1、​5EO0,%%s1AGB、​1AGC、​1AGD、​1AGE、​1AGF、​1M05、​1MI5、​3FFC、​3SJV、​3SKM、​3SKO、​3SPV、​3X13、​3X14、​4QRP、​4QRQ、​4QRS、​4QRT、​4QRU,%%s4O2C、​4O2E、​4O2F,%%s3LN4、​3LN5,%%s4U1J、​4U1M、​4U1N,%%s4U1I、​4U1L、​4U1S,%%s1HSA、​1JGD、​1JGE、​1K5N、​1OF2、​1OGT、​1UXS、​1UXW、​1W0V、​1W0W、​2A83、​2BSR、​2BSS、​2BST、​3B3I、​3B6S、​3BP4、​3BP7、​3CZF、​3D18、​3DTX、​3HCV、​3LV3、​4G8G、​4G8I、​4G9D、​4G9F、​5DEF、​5DEG,%%s1A1N、​1A9B、​1A9E、​1CG9、​1XH3、​1ZHK、​1ZHL、​1ZSD、​2AK4、​2AXF、​2AXG、​2H6P、​2NW3、​2NX5、​3BW9、​3BWA、​3KWW、​3KXF、​3LKN、​3LKO、​3LKP、​3LKQ、​3LKR、​3LKS、​3MV7、​3MV8、​3MV9、​3VFS、​3VFT、​3VFU、​3VFV、​3VFW、​4LNR、​4PR5、​4PRN、​4QRR,%%s1A1M、​1A1O,%%s2BVO、​2BVP、​2BVQ、​2HJL、​2RFX、​2YPK、​2YPL、​3UPR、​3VH8、​3VRI、​3VRJ、​3WUW、​3X11、​3X12、​5B39、​5B38,%%s4JQV、​4XXC,%%s1XR8、​1XR9、​3C9N,%%s4LCY,%%s1M6O、​1N2R、​1SYV、​3DX6、​3DX7、​3DX8、​3DXA、​3KPL、​3KPM、​3KPN、​3KPO、​3KPP、​3KPQ、​3KPR、​3KPS、​3L3D、​3L3G、​3L3I、​3L3J、​4JQX,%%s1E27、​1E28、​4MJI,%%s3W39
识别号
别名	HLA-B；, AS, SPDA1, Bw-47, Bw-50, major histocompatibility complex, class I, B, B-4901, B-5001, HEL-S-83, HLA-B*45ZJ, HLA-B-3506, HLA-B-3905, HLA-B-5502, HLA-B-5602, HLA-B15, HLA-B39, HLA-B49, HLA-B50, HLA-B55, HLA-B59, HLA-B61, HLA-Cw, HLA-DRB1
外部ID	HomoloGene：134029 GeneCards：HLA-B
相关疾病
人类免疫缺陷病毒传染性疾病
基因位置（人类） 染色体 6号染色体 基因座 6p21.33 起始 31,353,872 bp 终止 31,367,067 bp
RNA表达模式
查阅更多表达数据
基因本体 分子功能 • signaling receptor binding • peptide antigen binding 细胞组分 • integral component of membrane • phagocytic vesicle membrane • 高尔基体 • early endosome membrane • 膜 • Golgi membrane • 细胞膜 • integral component of plasma membrane • cell surface • 内质网 • MHC class I protein complex • ER to Golgi transport vesicle membrane • integral component of lumenal side of endoplasmic reticulum membrane • 外排体 • secretory granule membrane • recycling endosome membrane 生物学过程 • antigen processing and presentation • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent • regulation of interleukin-12 production • interferon-gamma-mediated signaling pathway • immune system process • antigen processing and presentation of peptide antigen via MHC class I • regulation of dendritic cell differentiation • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent • protection from natural killer cell mediated cytotoxicity • type I interferon signaling pathway • 免疫反应 • regulation of immune response • regulation of T cell anergy • viral process • regulation of interleukin-6 production • neutrophil degranulation Sources:Amigo / QuickGO
直系同源
物种	人类	小鼠
Entrez	3106	无数据
Ensembl	ENSG00000228964 ​ENSG00000234745 ​ENSG00000206450 ​ENSG00000224608 ​ENSG00000223532 ​ENSG00000232126	无数据
UniProt	P01889	无数据
mRNA​序列	NM_005514	无数据
蛋白序列	NP_005505	无数据
基因位置​（UCSC）	Chr 6: 31.35 – 31.37 Mb	无数据
PubMed​查找		无数据
维基数据
查看/编辑人类

延伸阅读

• Brown MA, Crane AM, Wordsworth BP. Genetic aspects of susceptibility, severity, and clinical expression in ankylosing spondylitis. Curr Opin Rheumatol. 2002, 14 (4): 354–60. PMID 12118167. doi:10.1097/00002281-200207000-00004. 
• Carrington M, O'Brien SJ. The influence of HLA genotype on AIDS. Annu Rev Med. 2003, 54: 535–51. PMID 12525683. doi:10.1146/annurev.med.54.101601.152346. 
• Chung WH, Hung SI, Hong HS, Hsih MS, Yang LC, Ho HC, Wu JY, Chen YT. Medical genetics: a marker for Stevens–Johnson syndrome. Nature. 2004, 428 (6982): 486. Bibcode:2004Natur.428..486C. PMID 15057820. doi:10.1038/428486a. 
• Colbert RA. The immunobiology of HLA-B27: variations on a theme. Curr Mol Med. 2004, 4 (1): 21–30. PMID 15011956. doi:10.2174/1566524043479293. 
• Colmegna I, Cuchacovich R, Espinoza LR. HLA-B27-associated reactive arthritis: pathogenetic and clinical considerations. Clin Microbiol Rev. 2004, 17 (2): 348–69. PMC 387405 . PMID 15084505. doi:10.1128/CMR.17.2.348-369.2004.  Full text
• Cooke GS, Hill AV. Genetics of susceptibility to human infectious disease. Nat Rev Genet. 2001, 2 (12): 967–77. PMID 11733749. doi:10.1038/35103577. 
• Gao X, Nelson GW, Karacki P, Martin MP, Phair J, Kaslow R, Goedert JJ, Buchbinder S, Hoots K, Vlahov D, O'Brien SJ, Carrington M. Effect of a single amino acid change in MHC class I molecules on the rate of progression to AIDS. N Engl J Med. 2001, 344 (22): 1668–75. PMID 11386265. doi:10.1056/NEJM200105313442203. 
• Hetherington S, Hughes AR, Mosteller M, Shortino D, Baker KL, Spreen W, Lai E, Davies K, Handley A, Dow DJ, Fling ME, Stocum M, Bowman C, Thurmond LM, Roses AD. Genetic variations in HLA-B region and hypersensitivity reactions to abacavir. Lancet. 2002, 359 (9312): 1121–2. PMID 11943262. doi:10.1016/S0140-6736(02)08158-8. 
• Hung SI, Chung WH, Liou LB, Chu CC, Lin M, Huang HP, Lin YL, Lan JL, Yang LC, Hong HS, Chen MJ, Lai PC, Wu MS, Chu CY, Wang KH, Chen CH, Fann CS, Wu JY, Chen YT. HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol. Proc Natl Acad Sci USA. 2005, 102 (11): 4134–9. Bibcode:2005PNAS..102.4134H. PMC 554812 . PMID 15743917. doi:10.1073/pnas.0409500102.  Full text
• Khan MA, Ball EJ. Genetic aspects of ankylosing spondylitis. Best Pract Res Clin Rheumatol. 2002, 16 (4): 675–90. PMID 12406434. 
• Khan MA. Update on spondyloarthropathies. Ann Intern Med. 2002, 136 (12): 896–907. PMID 12069564.  Full text (PDF)（页面存档备份，存于互联网档案馆）
• Letvin NL, Walker BD. Immunopathogenesis and immunotherapy in AIDS virus infections. Nat Med. 2003, 9 (7): 861–6. PMID 12835706. doi:10.1038/nm0703-861. 
• Migueles SA, Sabbaghian MS, Shupert WL, Bettinotti MP, Marincola FM, Martino L, Hallahan CW, Selig SM, Schwartz D, Sullivan J, Connors M. HLA B*5701 is highly associated with restriction of virus replication in a subgroup of HIV-infected long term nonprogressors. Proc Natl Acad Sci USA. 2000, 97 (6): 2709–14. Bibcode:2000PNAS...97.2709M. PMC 15994 . PMID 10694578. doi:10.1073/pnas.050567397.  Full text（页面存档备份，存于互联网档案馆）
• Sheehan NJ. The ramifications of HLA-B27. J R Soc Med. 2004, 97 (1): 10–4. PMC 1079257 . PMID 14702356. doi:10.1258/jrsm.97.1.10. 
• Tassaneeyakul W, Jantararoungtong T, Chen P, Lin PY, Tiamkao S, Khunarkornsiri U, Chucherd P, Konyoung P, Vannaprasaht S, Choonhakarn C, Pisuttimarn P, Sangviroon A, Tassaneeyakul W. Strong association between HLA-B*5801 and allopurinol-induced Stevens–Johnson syndrome and toxic epidermal necrolysis in a Thai population. Pharmacogenet Genomics. 2009, 19 (9): 704–9. PMID 19696695. doi:10.1097/FPC.0b013e328330a3b8. 
• Tassaneeyakul W, Tiamkao S, Jantararoungtong T, Chen P, Lin SY, Chen WH, Konyoung P, Khunarkornsiri U, Auvichayapat N, Pavakul K, Kulkantrakorn K, Choonhakarn C, Phonhiamhan S, Piyatrakul N, Aungaree T, Pongpakdee S, Yodnopaglaw P. Association between HLA-B*1502 and carbamazepine–induced severe cutaneous adverse drug reactions in a Thai population. Epilepsia. 2010, 51 (5): 926–30. PMID 20345939. doi:10.1111/j.1528-1167.2010.02533.x.  Full text(PDF)（页面存档备份，存于互联网档案馆）

This article incorporates public domain text from The U.S. National Library of Medicine（页面存档备份，存于互联网档案馆）

外部链接

• OMIM 142830
• EntrezGene 3106
• Template:GeneCard
• Nomenclature for factors of the HLA system