茯苓酸(英語:Pachymic acid)是一種天然的羊毛甾烷衍生甾體物質,提取自一種寄生真菌茯苓Wolfiporia extensa)也是一種傳統中醫學藥材[1]

茯苓酸
IUPAC名
3-Acetoxy-16-hydroxy-24-methylenelanost-8-en-21-oic acid
系統名
(2R)-2-[(3S,5R,10S,13R,14R,16R,17R)-3-acetyloxy-16-hydroxy-4,4,10,13,14-pentamethyl-2,3,5,6,7,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-6-methyl-5-methylideneheptanoic acid
識別
CAS號 29070-92-6  checkY
PubChem 5484385
ChemSpider 280037
SMILES
 
  • CC(C)C(=C)CC[C@H]([C@H]1[C@@H](C[C@@]2([C@@]1(CCC3=C2CC[C@@H]4[C@@]3(CC[C@@H](C4(C)C)OC(=O)C)C)C)C)O)C(=O)O
InChI
 
  • 1S/C33H52O5/c1-19(2)20(3)10-11-22(29(36)37)28-25(35)18-33(9)24-12-13-26-30(5,6)27(38-21(4)34)15-16-31(26,7)23(24)14-17-32(28,33)8/h19,22,25-28,35H,3,10-18H2,1-2,4-9H3,(H,36,37)/t22-,25-,26+,27+,28+,31-,32-,33+/m1/s1
InChIKey VDYCLYGKCGVBHN-DRCQUEPLSA-N
KEGG C17044
性質
化學式 C33H52O5
莫耳質量 528.76 g/mol g·mol⁻¹
密度 1.1±0.1 g/cm3
沸點 612.2±55.0 °C at 760 mmHg
危險性
閃點 184.7±25.0 °C [來源請求]
若非註明,所有數據均出自標準狀態(25 ℃,100 kPa)下。

效應

茯苓酸可以抑制EB病毒,並且可以抑制蛇毒中的磷脂酶A2[2],也有抗腫瘤和抗炎活性[1]

參考文獻

  1. ^ 1.0 1.1 Shu, Shaohua; Chen, Bei; Zhou, Mengchun; Zhao, Xinmei; Xia, Haiyang; Wang, Mo. De Novo Sequencing and Transcriptome Analysis of Wolfiporia cocos to Reveal Genes Related to Biosynthesis of Triterpenoids. PLOS ONE. 2013, 8 (8): e71350. PMC 3743799 . PMID 23967197. doi:10.1371/journal.pone.0071350. 
  2. ^ Pachymic acid Biological Test Results. PubChem compound database. 3 March 2016 [2019-06-30]. (原始內容存檔於2016-03-21).