維基百科

視網膜母細胞瘤蛋白

在智人中發現的哺乳動物蛋白質

視網膜母細胞瘤蛋白（英語：retinoblastoma protein，常縮寫為Rb、RB或RB1）又譯為成視網膜細胞瘤蛋白是一種抑癌蛋白，並在幾種主要的癌症發生時失活[6]。Rb的功能之一是通過抑制細胞周期進程直到細胞準備妥當來防止細胞過度生長。當細胞準備好要分裂時，Rb蛋白會被磷酸化為pRb而失去抑制活性，從而使細胞周期進行下去。

視網膜母細胞瘤蛋白
已知的結構
PDB直系同源搜尋: PDBe RCSB
識別號
別名RB1；, pRb, RB, retinoblastoma 1, OSRC, PPP1R130, p105-Rb, pp110, Retinoblastoma protein, RB transcriptional corepressor 1, p110-RB1
外部IDOMIM：614041 MGI：97874 HomoloGene：272 GeneCards：RB1
相關疾病
膀胱癌、​lung small cell carcinoma、​familial retinoblastoma[1]
基因位置（人類）
13號染色體
染色體13號染色體[2]
13號染色體
視網膜母細胞瘤蛋白的基因位置
視網膜母細胞瘤蛋白的基因位置
基因座13q14.2起始48,303,744 bp[2]
終止48,599,436 bp[2]
RNA表現模式


查閱更多表現資料
直系同源
物種人類小鼠
Entrez

5925

19645

Ensembl

ENSG00000139687

ENSMUSG00000022105

UniProt

P06400

P13405

mRNA​序列

NM_000321

NM_009029

蛋白序列

NP_000312
NP_000312.2

NP_033055

基因位置​（UCSC）Chr 13: 48.3 – 48.6 MbChr 14: 73.42 – 73.56 Mb
PubMed​查找[4][5]
維基資料
檢視/編輯人類檢視/編輯小鼠

Rb是袋狀蛋白家族的一員，其特點是有一個口袋狀的結構用以結合其它蛋白[7][8]。使得一些致癌變蛋白，比如高危險群人類乳突病毒所感染的細胞產生的蛋白，結合併抑制pRb，最終導致癌症。


相互作用

已知Rb蛋白與下列蛋白質有相互作用關係：

 
細胞凋亡中涉及的信號通路一覽

參考文獻

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