麩胺醯胺基肽酶

麩胺醯胺基肽酶,又稱胺基肽酶A,舊稱血管收縮素酶A[1]。它由ENPEP基因編碼,且高度保守[2]。麩胺醯胺基肽酶是一種膜結合鋅蛋白,能催化麩胺酸天門冬胺酸從肽鏈的N末端水解。例如,把血管收縮素IIN末端天門冬胺酸水解而轉化血管收縮素III。這個降解過程是哺乳動物調節局部血壓的一個重要步驟[1][3]。麩胺醯胺基肽酶被指定為CD249

麩胺醯胺基肽酶 (胺基肽酶A)
識別
符號 ENPEP
替換符號 gp160, CD249
Entrez 2028
HUGO 3355
OMIM 138297
RefSeq NM_001977
UniProt Q07075
其他資料
EC編號 3.4.11.7
基因座 4 q25

參考文獻

  1. ^ 1.0 1.1 Kugler P. Aminopeptidase A is angiotensinase A. II. Biochemical studies on aminopeptidase A and M in rat kidney homogenate.. Histochemistry. 1982, 74 (2): 247–61. PMID 6129208. 
  2. ^ Li L, Wu Q, Wang J, Bucy RP, Cooper MD. Widespread tissue distribution of aminopeptidase A, an evolutionarily conserved ectoenzyme recognized by the BP-1 antibody.. Tissue Antigens. 1993, 42 (5): 488 – 96. PMID 8146860. 
  3. ^ Reaux A, Iturrioz X, Vazeux G, Fournie-Zaluski MC, David C, Roques BP, Corvol P, Llorens-Cortes C. Aminopeptidase A, which generates one of the main effector peptides of the brain renin-angiotensin system, angiotensin III, has a key role in central control of arterial blood pressure. Biochem. Soc. Trans. 2000, 28 (4): 435–40. PMID 10961935.