阿來司酮

阿來司酮INN:aglepristone;開發代號:RU-46534RU-534),或譯安哥司酮,是一種與米非司酮相關的合成類甾體抗孕激素英語Antiprogestogen,由維克英語Virbac在幾個歐洲國家銷售,用作獸藥[1][2][3]它專門用作妊娠動物的墮胎藥英語Abortifacient[1][3][4]阿來司酮也具有一些抗糖皮質激素英語Antiglucocorticoid活性。[5][6]

阿來司酮
臨床資料
商品名英語Drug nomenclatureAlizin
其他名稱安哥司酮、RU-46534、RU-534
藥物類別英語Drug class抗孕激素英語Antiprogestogen抗糖皮質激素英語Antiglucocorticoid
ATC碼
識別資訊
  • (8S,11R,13S,14S,17R)-11-[4-(dimethylamino)phenyl]-17-hydroxy-13-methyl-17-[(Z)-prop-1-enyl]-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
CAS號124478-60-0
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard英語CompTox Chemicals Dashboard (EPA)
ECHA InfoCard100.211.372 編輯維基數據鏈接
化學資訊
化學式C29H37NO2
摩爾質量431.62 g·mol−1
3D模型(JSmol英語JSmol
  • C/C=C\[C@@]1(CC[C@@H]2[C@@]1(C[C@@H](C3=C4CCC(=O)C=C4CC[C@@H]23)C5=CC=C(C=C5)N(C)C)C)O
  • InChI=1S/C29H37NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h5-7,9-10,15,17,24-26,32H,8,11-14,16,18H2,1-4H3/b15-5-/t24-,25+,26-,28-,29-/m0/s1
  • Key:RTCKAOKDXNYXEH-FWSJOHTJSA-N

參考資料

  1. ^ 1.0 1.1 Kaufman LK, Baldwin CJ. Pregancy Loss in the Bitch and Queen. Bonagura JD, Twedt DC (編). Kirk's Current Veterinary Therapy XV. Elsevier Health Sciences. 1 December 2013: 3009–. ISBN 978-0-323-22762-9. 
  2. ^ Squires EJ. Endocrine manipulation of reproduction.. Applied Animal Endocrinology. CABI. 2010: 207–. ISBN 978-1-84593-755-3. 
  3. ^ 3.0 3.1 Papich MC. Aglepristone. Saunders Handbook of Veterinary Drugs: Small and Large Animal. Elsevier Health Sciences. 3 November 2010: 120–. ISBN 978-1-4377-0192-0. 
  4. ^ Fieni F, Martal J, Marnet PG, Siliart B, Bernard F, Riou M, Bruyas JF, Tainturier D. Concannon PW , 編. Hormonal variation in bitches after early or mid-pregnancy termination with aglepristone (RU534). Journal of Reproduction and Fertility. Supplement. Advances in reproduction in dogs, cats and exotic carnivores: proceedings of the fourth International Symposium on Canine and Feline Reproduction, Oslo, Norway, 29 June-1 July 2000. 2001, 57: 243–8. ISBN 978-0-906545-37-9. PMID 11787157. 
  5. ^ Batista M, Reyes R, Santana M, Alamo D, Vilar J, González F, et al. Induction of parturition with aglepristone in the Majorera goat. Reproduction in Domestic Animals = Zuchthygiene. October 2011, 46 (5): 882–888. PMID 21320179. doi:10.1111/j.1439-0531.2011.01759.x. 
  6. ^ Baan M, Taverne MA, de Gier J, Kooistra HS, Kindahl H, Dieleman SJ, Okkens AC. Hormonal changes in spontaneous and aglépristone-induced parturition in dogs. Theriogenology. March 2008, 69 (4): 399–407. PMID 18054071. doi:10.1016/j.theriogenology.2007.10.008.